Ace View of C15H11.7 | |||||||
C15H11.7 Details | |||||||
Description | pas-1 encodes a type 6 alpha subunit of the 26S proteasome's 20S protease core particle (CP); PAS-1 is required for embryonic development and by homology, is predicted to comprise the outer rings of the proteasome and to play a role in selective degradation of ubiquitinated proteins during development; in vitro, PAS-1 interacts with VET-1, a coiled-coil domain-containing protein expressed in the early embryo and ATN-1, an alpha-actinin, in addition to other members of the proteasome. | ||||||
Homology Group (KOG) | 20S proteasome, regulatory subunit alpha type PSMA6/SCL1 |
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GO Terms | threonine endopeptidase activity (GO:0004298) ; ubiquitin-dependent protein catabolism (GO:0006511) ; proteasome core complex (sensu Eukarya) (GO:0005839) ; endopeptidase activity (GO:0004175) | ||||||
Location | V:14423772..14425609 | ||||||
RNAi Phenotypes |
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External Links | |||||||
Associated RNAi Experiments | |||||||
Cenix:38-e7 | |||||||
Embryonic Phenotypes | Emb Penetrance None reported | ||||||
Adult Phenotypes | Passage Through Meiosis defective |
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RNAi Reagent Name & Type | Cenix:38-e7 (PCR reagent) | ||||||
Delivery Method | Injection | ||||||
Remark | early embryonic: Passage Through Meiosis | ||||||
Laboratory | TH | ||||||
Date | 2005-3-24 | ||||||
Reference | Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...." | ||||||
Gene Plot of C15H11.7 | |||||||