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Gene/ORF C15H11.7 (pas-1) Ace View of C15H11.7
C15H11.7 Details Help
Description  pas-1 encodes a type 6 alpha subunit of the 26S proteasome's 20S protease core particle (CP); PAS-1 is required for embryonic development and by homology, is predicted to comprise the outer rings of the proteasome and to play a role in selective degradation of ubiquitinated proteins during development; in vitro, PAS-1 interacts with VET-1, a coiled-coil domain-containing protein expressed in the early embryo and ATN-1, an alpha-actinin, in addition to other members of the proteasome.
Homology Group (KOG)  20S proteasome, regulatory subunit alpha type PSMA6/SCL1
GO Terms  threonine endopeptidase activity (GO:0004298) ; ubiquitin-dependent protein catabolism (GO:0006511) ; proteasome core complex (sensu Eukarya) (GO:0005839) ; endopeptidase activity (GO:0004175)
Location   V:14423772..14425609
RNAi Phenotypes
Early_embryo Passage Through Meiosis defective
Larva Lva
Adult Lon ; Ste ; Unc
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Details
Embryonic Phenotypes  Emb Penetrance None reported
Adult Phenotypes  Passage Through Meiosis defective
RNAi Reagent Name & Type Cenix:38-e7 (PCR reagent)
Delivery Method  Injection
Remark  early embryonic: Passage Through Meiosis
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
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