Ace View of C15H9.6 | |||||
C15H9.6 Details | |||||
Description | hsp-3 encodes a heat shock response 70 (hsp70) protein orthologous to human glucose regulated protein 78 (grp78/BiP, OMIM:138120); HSP-3 likely functions as a molecular chaperone, and is expressed constitutively (expression is not heat inducible) throughout development with greatest abundance during the L1 larval stage; HSP-3 contains a long hydrophobic amino terminus and a carboxyl terminal KDEL sequence suggesting that it may be retained in the endoplasmic reticulum. | ||||
Homology Group (KOG) | Molecular chaperones GRP78/BiP/KAR2, HSP70 superfamily |
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GO Terms | response to chemical substance (GO:0042221) ; protein secretion (GO:0009306) ; response to stress (GO:0006950) ; endoplasmic reticulum lumen (GO:0005788) ; ATPase activity (GO:0016887) ; protein binding (GO:0005515) ; calcium ion binding (GO:0005509) ; ATP binding (GO:0005524) | ||||
Location | X:6088603..6092482 | ||||
RNAi Phenotypes |
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External Links | |||||
Associated RNAi Experiments | |||||
Cenix:22-a6 | |||||
Adult Phenotypes | WT |
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RNAi Reagent Name & Type | Cenix:22-a6 (PCR reagent) | ||||
Delivery Method | Injection | ||||
Remark | early embryonic: Three independent experiments, two of which showed low reprocucible defects. | ||||
Laboratory | TH | ||||
Date | 2005-3-24 | ||||
Reference | Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...." | ||||
Simmer:C15H9.6 | |||||
Larval Phenotypes | Lva |
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Adult Phenotypes | Dpy |
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RNAi Reagent Name & Type | sjj_C15H9.6 (PCR reagent) | ||||
Laboratory | NL | ||||
Date | 2003-10-01 | ||||
Strain | NL4256 rrf-3(pk1426) | ||||
Reference | Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...." | ||||
Gene Plot of C15H9.6 | |||||