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Gene/ORF C15H9.6 (hsp-3) Ace View of C15H9.6
C15H9.6 Details Help
Description  hsp-3 encodes a heat shock response 70 (hsp70) protein orthologous to human glucose regulated protein 78 (grp78/BiP, OMIM:138120); HSP-3 likely functions as a molecular chaperone, and is expressed constitutively (expression is not heat inducible) throughout development with greatest abundance during the L1 larval stage; HSP-3 contains a long hydrophobic amino terminus and a carboxyl terminal KDEL sequence suggesting that it may be retained in the endoplasmic reticulum.
Homology Group (KOG)  Molecular chaperones GRP78/BiP/KAR2, HSP70 superfamily
GO Terms  response to chemical substance (GO:0042221) ; protein secretion (GO:0009306) ; response to stress (GO:0006950) ; endoplasmic reticulum lumen (GO:0005788) ; ATPase activity (GO:0016887) ; protein binding (GO:0005515) ; calcium ion binding (GO:0005509) ; ATP binding (GO:0005524)
Location   X:6088603..6092482
RNAi Phenotypes
Larva Lva
Adult Dpy ; Ste
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Details
Cenix:22-a6
Adult Phenotypes  WT
RNAi Reagent Name & Type Cenix:22-a6 (PCR reagent)
Delivery Method  Injection
Remark  early embryonic: Three independent experiments, two of which showed low reprocucible defects.
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
Simmer:C15H9.6
Larval Phenotypes  Lva
Adult Phenotypes  Dpy
RNAi Reagent Name & Type sjj_C15H9.6 (PCR reagent)
Laboratory  NL
Date  2003-10-01
Strain  NL4256 rrf-3(pk1426)
Reference  Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...."
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