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Gene/ORF C23G10.4 (rpn-2) Ace View of C23G10.4
C23G10.4 Details Help
Description  rpn-2 encodes a non-ATPase subunit of the 26S proteasome's 19S regulatory paritcle (RP) base subcomplex; RPN-2 is required for embryonic, larval, and germline development and by homology, is predicted to function in unfolding and recognition of protein substrates and/or recycling of ubiquitin moieties during protein degradation; RPN-2 is expressed sporadically at all stages of development in the pharynx, intestine, body wall muscle, somatic gonad, neurons, and hypodermis.
Homology Group (KOG)  26S proteasome regulatory complex, subunit RPN2/PSMD1
GO Terms  regulation of cell cycle (GO:0000074) ; binding (GO:0005488)
Location   III:6198725..6202933
RNAi Phenotypes
Early_embryo Passage Through Meiosis defective ; Passage Through Meiosis defective
Larva Lvl
Adult Sck ; Ste
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Summary
Cenix:137-f8
Embryonic Phenotypes  Emb Penetrance None reported
Adult Phenotypes  Passage Through Meiosis defective
RNAi Reagent Name & Type Cenix:137-f8 (PCR reagent)
Delivery Method  Injection
Remark  early embryonic: Passage Through Meiosis
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
Cenix:314-d3
Embryonic Phenotypes  Emb Penetrance None reported
Adult Phenotypes  Passage Through Meiosis defective
RNAi Reagent Name & Type Cenix:314-d3 (PCR reagent)
Delivery Method  Injection
Remark  early embryonic: Passage Through Meiosis
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
JA:C23G10.4
Adult Phenotypes  Sck
Ste
RNAi Reagent Name & Type sjj_C23G10.4 (PCR reagent)
Laboratory  JA
Date  2003-1-10
Reference  Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...."
Simmer:C23G10.4
Embryonic Phenotypes  Emb Penetrance 100 %
RNAi Reagent Name & Type sjj_C23G10.4 (PCR reagent)
Laboratory  NL
Date  2003-10-01
Strain  NL4256 rrf-3(pk1426)
Reference  Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...."
TH:314d3
Embryonic Phenotypes  Emb Penetrance None reported
RNAi Reagent Name & Type TH:314d3 (PCR reagent)
Remark  Phenotype comment -- Confirmed with independent dsRNA (C23G10.4-RNA2; similar DIC phenotype, but progeny test was not embryonic lethal).
Laboratory  TH
Date  2000-11-16
Reference  Gonczy P et al. (2000) Nature "Functional genomic analysis of cell division in C. elegans using RNAi of genes on ...."
TH:341g12
Embryonic Phenotypes  Emb Penetrance None reported
RNAi Reagent Name & Type TH:341g12 (PCR reagent)
Remark  Phenotype comment -- Confirmed with independent dsRNA (C23G10.4-RNA2; similar DIC phenotype, but progeny test was not embryonic lethal).
Laboratory  TH
Date  2000-11-16
Reference  Gonczy P et al. (2000) Nature "Functional genomic analysis of cell division in C. elegans using RNAi of genes on ...."
Gene Plot of C23G10.4 Browse using GBrowse
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