Gene/ORF
C23G10.4 (rpn-2)
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Ace View of C23G10.4
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C23G10.4 Details |
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Description |
rpn-2 encodes a non-ATPase subunit of the 26S proteasome's 19S regulatory paritcle (RP) base subcomplex; RPN-2 is required for embryonic, larval, and germline development and by homology, is predicted to function in unfolding and recognition of protein substrates and/or recycling of ubiquitin moieties during protein degradation; RPN-2 is expressed sporadically at all stages of development in the pharynx, intestine, body wall muscle, somatic gonad, neurons, and hypodermis. |
Homology Group (KOG) |
26S proteasome regulatory complex, subunit RPN2/PSMD1
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GO Terms |
regulation of cell cycle
(GO:0000074) ; binding
(GO:0005488) |
Location |
III:6198725..6202933 |
RNAi Phenotypes |
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External Links |
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Associated RNAi Experiments |
View Summary
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Cenix:137-f8
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Embryonic Phenotypes |
Emb Penetrance None reported |
Adult Phenotypes |
Passage Through Meiosis defective
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RNAi Reagent Name & Type |
Cenix:137-f8 (PCR reagent) |
Delivery Method |
Injection |
Remark |
early embryonic: Passage Through Meiosis |
Laboratory |
TH |
Date |
2005-3-24 |
Reference |
Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...." |
Cenix:314-d3
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Embryonic Phenotypes |
Emb Penetrance None reported |
Adult Phenotypes |
Passage Through Meiosis defective
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RNAi Reagent Name & Type |
Cenix:314-d3 (PCR reagent) |
Delivery Method |
Injection |
Remark |
early embryonic: Passage Through Meiosis |
Laboratory |
TH |
Date |
2005-3-24 |
Reference |
Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...." |
JA:C23G10.4
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Adult Phenotypes |
Sck Ste
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RNAi Reagent Name & Type |
sjj_C23G10.4 (PCR reagent) |
Laboratory |
JA |
Date |
2003-1-10 |
Reference |
Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...." |
Simmer:C23G10.4
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Embryonic Phenotypes |
Emb Penetrance 100 % |
RNAi Reagent Name & Type |
sjj_C23G10.4 (PCR reagent) |
Laboratory |
NL |
Date |
2003-10-01 |
Strain |
NL4256 rrf-3(pk1426) |
Reference |
Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...." |
TH:314d3
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Embryonic Phenotypes |
Emb Penetrance None reported |
RNAi Reagent Name & Type |
TH:314d3 (PCR reagent) |
Remark |
Phenotype comment -- Confirmed with independent dsRNA (C23G10.4-RNA2; similar DIC phenotype, but progeny test was not embryonic lethal). |
Laboratory |
TH |
Date |
2000-11-16 |
Reference |
Gonczy P et al. (2000) Nature "Functional genomic analysis of cell division in C. elegans using RNAi of genes on ...." |
TH:341g12
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Embryonic Phenotypes |
Emb Penetrance None reported |
RNAi Reagent Name & Type |
TH:341g12 (PCR reagent) |
Remark |
Phenotype comment -- Confirmed with independent dsRNA (C23G10.4-RNA2; similar DIC phenotype, but progeny test was not embryonic lethal). |
Laboratory |
TH |
Date |
2000-11-16 |
Reference |
Gonczy P et al. (2000) Nature "Functional genomic analysis of cell division in C. elegans using RNAi of genes on ...." |
Gene Plot of C23G10.4 |
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