Ace View of C25A11.4 | |||||
C25A11.4 Details | |||||
Description | ajm-1 encodes a member of the apical junction molecule class that is required for correct elongation of the C. elegans embryo; AJM-1 contains a coiled-coil motif; AJM-1 binds DLG-1 in vitro, in yeast two-hybrid assays, and in vivo; AJM-1 is mislocalized in a dlg-1(RNAi) background; LET-413 is required for rapid confinement of DLG-1 and AJM-1 to a narrow apical region in C. elegans epithelia; CLC-1 colocalizes with AJM-1; vab-9 mutations enhance the adhesion defects of ajm-1 mutants; ajm-1 is expressed at the apical borders of all epithelia. | ||||
GO Terms | embryonic development (GO:0009790) ; intercellular junction assembly and/or maintenance (GO:0045216) ; cell-cell adherens junction (GO:0005913) ; cytoskeletal protein binding (GO:0008092) | ||||
Location | X:9097881..9113935 | ||||
RNAi Phenotypes |
|
||||
External Links | |||||
Associated RNAi Experiments | |||||
Cenix:146-f2 | |||||
Adult Phenotypes | WT |
||||
RNAi Reagent Name & Type | Cenix:146-f2 (PCR reagent) | ||||
Delivery Method | Injection | ||||
Remark | 3/3 tests with wildtype results. | ||||
Laboratory | TH | ||||
Date | 2005-3-24 | ||||
Reference | Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...." | ||||
Cenix:34-e11 | |||||
Adult Phenotypes | WT |
||||
RNAi Reagent Name & Type | Cenix:34-e11 (PCR reagent) | ||||
Delivery Method | Injection | ||||
Remark | early embryonic: Not the best quality for some of the recordings. However, all events are sufficiently captured to evaluate this test as wildtype. | ||||
Laboratory | TH | ||||
Date | 2005-3-24 | ||||
Reference | Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...." | ||||
JA:C25A11.3 | |||||
Adult Phenotypes | WT |
||||
RNAi Reagent Name & Type | sjj_C25A11.3 (PCR reagent) | ||||
Laboratory | JA | ||||
Date | 2003-1-10 | ||||
Reference | Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...." | ||||
JA:C25A11.4 | |||||
Adult Phenotypes | WT |
||||
RNAi Reagent Name & Type | sjj_C25A11.4 (PCR reagent) | ||||
Laboratory | JA | ||||
Date | 2003-1-10 | ||||
Reference | Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...." | ||||
Simmer:C25A11.4:Repeat_a | |||||
Embryonic Phenotypes | Emb Penetrance 50 - 80 % | ||||
Larval Phenotypes | Gro |
||||
Adult Phenotypes | Unc |
||||
RNAi Reagent Name & Type | sjj_C25A11.4 (PCR reagent) | ||||
Laboratory | NL | ||||
Date | 2003-10-01 | ||||
Strain | NL4256 rrf-3(pk1426) | ||||
Reference | Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...." | ||||
Simmer:C25A11.4:Screen | |||||
Embryonic Phenotypes | Emb Penetrance 100 % | ||||
RNAi Reagent Name & Type | sjj_C25A11.4 (PCR reagent) | ||||
Laboratory | NL | ||||
Date | 2003-10-01 | ||||
Strain | NL4256 rrf-3(pk1426) | ||||
Reference | Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...." | ||||
Gene Plot of C25A11.4 | |||||