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Gene/ORF C25A11.4 (ajm-1) Ace View of C25A11.4
C25A11.4 Details Help
Description  ajm-1 encodes a member of the apical junction molecule class that is required for correct elongation of the C. elegans embryo; AJM-1 contains a coiled-coil motif; AJM-1 binds DLG-1 in vitro, in yeast two-hybrid assays, and in vivo; AJM-1 is mislocalized in a dlg-1(RNAi) background; LET-413 is required for rapid confinement of DLG-1 and AJM-1 to a narrow apical region in C. elegans epithelia; CLC-1 colocalizes with AJM-1; vab-9 mutations enhance the adhesion defects of ajm-1 mutants; ajm-1 is expressed at the apical borders of all epithelia.
GO Terms  embryonic development (GO:0009790) ; intercellular junction assembly and/or maintenance (GO:0045216) ; cell-cell adherens junction (GO:0005913) ; cytoskeletal protein binding (GO:0008092)
Location   X:9097881..9113935
RNAi Phenotypes
Larva Gro
Adult Unc
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Summary
Cenix:146-f2
Adult Phenotypes  WT
RNAi Reagent Name & Type Cenix:146-f2 (PCR reagent)
Delivery Method  Injection
Remark  3/3 tests with wildtype results.
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
Cenix:34-e11
Adult Phenotypes  WT
RNAi Reagent Name & Type Cenix:34-e11 (PCR reagent)
Delivery Method  Injection
Remark  early embryonic: Not the best quality for some of the recordings. However, all events are sufficiently captured to evaluate this test as wildtype.
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
JA:C25A11.3
Adult Phenotypes  WT
RNAi Reagent Name & Type sjj_C25A11.3 (PCR reagent)
Laboratory  JA
Date  2003-1-10
Reference  Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...."
JA:C25A11.4
Adult Phenotypes  WT
RNAi Reagent Name & Type sjj_C25A11.4 (PCR reagent)
Laboratory  JA
Date  2003-1-10
Reference  Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...."
Simmer:C25A11.4:Repeat_a
Embryonic Phenotypes  Emb Penetrance 50 - 80 %
Larval Phenotypes  Gro
Adult Phenotypes  Unc
RNAi Reagent Name & Type sjj_C25A11.4 (PCR reagent)
Laboratory  NL
Date  2003-10-01
Strain  NL4256 rrf-3(pk1426)
Reference  Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...."
Simmer:C25A11.4:Screen
Embryonic Phenotypes  Emb Penetrance 100 %
RNAi Reagent Name & Type sjj_C25A11.4 (PCR reagent)
Laboratory  NL
Date  2003-10-01
Strain  NL4256 rrf-3(pk1426)
Reference  Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...."
Gene Plot of C25A11.4 Browse using GBrowse
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