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Gene/ORF C32F10.2 (lin-35) Ace View of C32F10.2
C32F10.2 Details Help
Description  lin-35 encodes the C. elegans retinoblastoma protein (Rb) ortholog; lin-35 was first identified in screens for synthetic multivulva (synMuv) genes and as a class B synMuv gene, functions redundantly with class A genes to antagonize Ras signaling and negatively regulate vulval development; in addition, lin-35 activity is required redundantly with: 1) pha-1 and ubc-18 for early steps in pharyngeal morphogenesis, 2) fzr-1 for normal patterns of postembryonic proliferation, 3) xnp-1 for somatic gonad development, and 4) psa-1 for fertility and embryonic and larval development; on its own, lin-35 is also required for wild-type levels of fertility; LIN-35 is expressed broadly in embryos and L1 larvae, but in later larvae and adults is detected in vulval precursor cells and their descendants as well as a subset of head and tail cells.
Homology Group (KOG)  Rb (Retinoblastoma tumor suppressor)-related protein
GO Terms  larval development (sensu Nematoda) (GO:0002119) ; positive regulation of body size (GO:0040018) ; reproduction (GO:0000003) ; embryonic development (sensu Animalia) (GO:0009792)
Location   I:5807312..5816040
RNAi Phenotypes
Larva Gro ; Gro
Adult Egl ; Rup
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Details
Wild Type RNAi Experiments
JA:C32F10.2 WT
Simmer:C32F10.2:Screen_B WT
Cenix:13-a9 WT
Experiments with Non-Wild Phenotypes
Simmer:C32F10.2:Screen_A Egl ; Gro
Simmer:C32F10.2:Repeat_b Gro
PF:GL1_8B5 Rup
Gene Plot of C32F10.2 Browse using GBrowse
Gene Map