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Gene/ORF C33H5.4 (klp-10) Ace View of C33H5.4
C33H5.4 Details Help
Description  klp-10 encodes a kinesin-like motor protein that displays similarity to diverse types of kinesin motor domains such as those found in C. elegans OSM-3, the vertebrate CHO1/MKLP proteins, and Saccharomyces cerevisiae Kip3; KLP-10 is required for embryogensis, may play a role in meiosis, and has been implicated in chromosome segregation and cell cycle progression.
GO Terms  microtubule motor activity (GO:0003777) ; ATP binding (GO:0005524) ; microtubule-based movement (GO:0007018) ; microtubule associated complex (GO:0005875)
Location   IV:7796704..7800782
RNAi Phenotypes
Early_embryo Indistinct maternal pronucleus ; Paternal pronucleus migrates ; Multiple nuclei in 1, 2, or 4-cell embryos ; Excessive blebbing ; Polar bodies abnormal ; Failure to form pronucleus ; Passage Through Meiosis defective ; P0 spindle positioning defect ; Loose mitotic furrow
Adult Him
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Summary
Cenix:12-b6
Embryonic Phenotypes  Emb Penetrance None reported
Adult Phenotypes  Passage Through Meiosis defective
RNAi Reagent Name & Type Cenix:12-b6 (PCR reagent)
Delivery Method  Injection
Remark  early embryonic: Polar Body Extrusion
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
Cenix:219-e3
Adult Phenotypes  WT
RNAi Reagent Name & Type Cenix:219-e3 (PCR reagent)
Delivery Method  Injection
Remark  Wildtype results in all three tests.
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
JA:C33H5.3
Adult Phenotypes  WT
RNAi Reagent Name & Type sjj_C33H5.3 (PCR reagent)
Laboratory  JA
Date  2003-1-10
Reference  Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...."
JA:C33H5.4
Embryonic Phenotypes  Emb Penetrance 100 %
Adult Phenotypes  Him
RNAi Reagent Name & Type sjj_C33H5.4 (PCR reagent)
Laboratory  JA
Date  2003-1-10
Reference  Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...."
PF:GL1_3F3
Embryonic Phenotypes  Emb Penetrance 100 %
Adult Phenotypes  Excessive blebbing
Failure to form pronucleus
Indistinct maternal pronucleus
Loose mitotic furrow
Multiple nuclei in 1, 2, or 4-cell embryos
P0 spindle positioning defect
Paternal pronucleus migrates
Polar bodies abnormal
RNAi Reagent Name & Type sjj_C33H5.4 (PCR reagent)
Delivery Method  Injection
Remark  PCR product contains flanking T7 promoter sequences
Laboratory  KK
Date  2002-11-19
Reference  Piano et al. (2002) Curr Biol "Gene Clustering Based on RNAi Phenotypes of Ovary-Enriched Genes in C. elegans"
Movies/Stacks/Images  /static/images/movie.gif /static/images/movie.gif /static/images/movie.gif
Simmer:C33H5.4
Embryonic Phenotypes  Emb Penetrance 90 %
RNAi Reagent Name & Type sjj_C33H5.4 (PCR reagent)
Laboratory  NL
Date  2003-10-01
Strain  NL4256 rrf-3(pk1426)
Reference  Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...."
Gene Plot of C33H5.4 Browse using GBrowse
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