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Gene/ORF C34C6.6 (prx-5) Ace View of C34C6.6
C34C6.6 Details Help
Description  prx-5 encodes an ortholog of the human receptor for type I peroxisomal targeting signal protein, PXR1 (or PEX5; OMIM:600414), which when mutated leads to neonatal adrenoleukodystrophy or Zellweger syndrome; PXR1 protein is a component of the peroxisomal import machinery known to exist in organisms like yeast, plants and mammals.
GO Terms  binding (GO:0005488)
Location   II:8704348..8707046
RNAi Phenotypes
Postembryonic WT_postembryonic_morphology
Larva Lva ; Lva ; Gro
Adult Clr
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Summary
JA:C34C6.6
Larval Phenotypes  Gro
Adult Phenotypes  Clr
RNAi Reagent Name & Type sjj_C34C6.6 (PCR reagent)
Laboratory  JA
Date  2003-1-10
Reference  Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...."
Simmer:C34C6.6
Larval Phenotypes  Lva
RNAi Reagent Name & Type sjj_C34C6.6 (PCR reagent)
Laboratory  NL
Date  2003-10-01
Strain  NL4256 rrf-3(pk1426)
Reference  Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...."
[cgc5655]:C34C6.6
Adult Phenotypes  Unclassified lipid metabolism abnormal
RNAi Reagent Name & Type sjj_C34C6.6 (PCR reagent)
Delivery Method  Bacterial_feeding
Laboratory  GR
Date  2003-1-10
Reference  Ashrafi K et al. (2003) Nature "Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory ...."
[cgc5655]:daf-2:C34C6.6
Adult Phenotypes  WTRNAi causes no change in fat content
RNAi Reagent Name & Type sjj_C34C6.6 (PCR reagent)
Delivery Method  Bacterial_feeding
Laboratory  GR
Date  2003-1-10
Strain  daf-2(e1370)
Reference  Ashrafi K et al. (2003) Nature "Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory ...."
[cgc5655]:tph-1:C34C6.6
Adult Phenotypes  WTRNAi causes no change in fat content
RNAi Reagent Name & Type sjj_C34C6.6 (PCR reagent)
Delivery Method  Bacterial_feeding
Laboratory  GR
Date  2003-1-10
Strain  tph-1(mg280)
Reference  Ashrafi K et al. (2003) Nature "Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory ...."
[cgc5655]:tub-1:C34C6.6
Adult Phenotypes  WTRNAi causes no change in fat content
RNAi Reagent Name & Type sjj_C34C6.6 (PCR reagent)
Delivery Method  Bacterial_feeding
Laboratory  GR
Date  2003-1-10
Strain  tub-1(nr2004)
Reference  Ashrafi K et al. (2003) Nature "Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory ...."
[pmid12181365]:PXR1
Larval Phenotypes  Lva
Adult Phenotypes  Unclassified a diffuse pattern of fluorescence of CFP-SKL (ser-lys-leu), characteristic of the cytosol, was observed, suggesting a deficiency in the peroxisomal import of PTS1-targeted matrix proteins
RNAi Reagent Name & Type [pmid12181365]:PXR1 (PCR reagent)
Delivery Method  Injection
Date  2002-8-14
Reference  Petriv OI et al. (2002) Physiological Genomics "RNA interference of peroxisome-related genes in C. elegans: a new model for human ...."
Cenix:20-c12
Embryonic Phenotypes  Emb Penetrance None reported
Adult Phenotypes  WT_postembryonic_morphology
RNAi Reagent Name & Type Cenix:20-c12 (PCR reagent)
Delivery Method  Injection
Remark  early embryonic: No reproducible defects observed.
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
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