Ace View of C36E8.5 | |||||
C36E8.5 Details | |||||
Description | tbb-2 encodes a homolog of mammalian beta-tubulin (TUBB) that is expressed at high levels in the germline; TBB-2 is redundant for embryonic viability, due to its paralog TBB-1; however, unlike its paralog TBB-1 it is preferred for normal microtubule severing by the katanin complex MEI-1/MEI-2; TBB-2 is required together with TBB-1, TBA-1, and tba-2 to make spindle structures in embryos and TBB-2 also affects the stability of the PO spindle; first divisions are normal in null mutants, but putative gain-of-function mutations affect centrosome rotations in the P0, P1, and EMS blastomeres of the early embryo, and affect pronuclear migration and meiosis. | ||||
Homology Group (KOG) | Beta tubulin |
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GO Terms | meiotic spindle assembly (GO:0000212) ; tubulin (GO:0045298) ; structural molecule activity (GO:0005198) ; microtubule-based movement (GO:0007018) ; microtubule (GO:0005874) ; GTP binding (GO:0005525) ; cytoplasm (GO:0005737) ; GTPase activity (GO:0003924) ; protein polymerization (GO:0051258) ; protein complex (GO:0043234) | ||||
Location | III:4015336..4018007 | ||||
RNAi Phenotypes |
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External Links | |||||
Associated RNAi Experiments | |||||
Experiments with Non-Wild Phenotypes | |||||
WBRNAi00038545 | Unclassified | ||||
TH:341d11 | Emb | ||||
Cenix:341-d11 | Emb ; Pnm | ||||
Simmer:C36E8.5 | Emb | ||||
TH:300c6 | Emb | ||||
Cenix:300-c6 | Emb ; Pnm | ||||
Gene Plot of C36E8.5 | |||||