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Gene/ORF C36E8.5 (tbb-2) Ace View of C36E8.5
C36E8.5 Details Help
Description  tbb-2 encodes a homolog of mammalian beta-tubulin (TUBB) that is expressed at high levels in the germline; TBB-2 is redundant for embryonic viability, due to its paralog TBB-1; however, unlike its paralog TBB-1 it is preferred for normal microtubule severing by the katanin complex MEI-1/MEI-2; TBB-2 is required together with TBB-1, TBA-1, and tba-2 to make spindle structures in embryos and TBB-2 also affects the stability of the PO spindle; first divisions are normal in null mutants, but putative gain-of-function mutations affect centrosome rotations in the P0, P1, and EMS blastomeres of the early embryo, and affect pronuclear migration and meiosis.
Homology Group (KOG)  Beta tubulin
GO Terms  meiotic spindle assembly (GO:0000212) ; tubulin (GO:0045298) ; structural molecule activity (GO:0005198) ; microtubule-based movement (GO:0007018) ; microtubule (GO:0005874) ; GTP binding (GO:0005525) ; cytoplasm (GO:0005737) ; GTPase activity (GO:0003924) ; protein polymerization (GO:0051258) ; protein complex (GO:0043234)
Location   III:4015336..4018007
RNAi Phenotypes
Early_embryo Pnm ; Pnm
Larva Lvl
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Details
Experiments with Non-Wild Phenotypes
WBRNAi00038545 Unclassified
TH:341d11 Emb
Cenix:341-d11 Emb ; Pnm
Simmer:C36E8.5 Emb
TH:300c6 Emb
Cenix:300-c6 Emb ; Pnm
Gene Plot of C36E8.5 Browse using GBrowse
Gene Map