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Gene/ORF C37C3.6 (ppn-1) Ace View of C37C3.6
C37C3.6 Details Help
Description  C37C3.6 encodes three isoforms of a large, novel multidomain glycoprotein orthologous to thrombospondin from Haemonchus contortus, papilin from D. melanogaster, and lacunin from Manduca sexta; the N-terminal region of C37C3.6 proteins have a domain set also found in the C-terminal region of ADAMTS matrix-associated metalloproteinases; C37C3.6 is generally required for normal cell arrangements, being required in embryos for viability and normal hypodermal enclosure, and in L1 larvae for normal excretory canal function.
GO Terms  metalloendopeptidase activity (GO:0004222) ; extracellular matrix (GO:0031012) ; serine protease inhibitor activity (GO:0004867) ; peptidase activity (GO:0008233)
Location   V:7829482..7845359
RNAi Phenotypes
Postembryonic Bli ; Larval Arrest-Late (L3/L4)
Larva Let ; Lva ; Gro
Adult Sck ; Pvl ; Pvl ; Ste ; Ste ; Unc ; Unc ; Rup ; Stp
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Summary
JA:C37C3.6
Embryonic Phenotypes  Emb Penetrance 10 %
Larval Phenotypes  Gro
Adult Phenotypes  Pvl
Rup
Stp brood size (6 out of 10)
Unc
RNAi Reagent Name & Type sjj_C37C3.6 (PCR reagent)
Laboratory  JA
Date  2003-1-10
Reference  Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...."
Simmer:C37C3.6
Larval Phenotypes  Lva
Adult Phenotypes  Unc
RNAi Reagent Name & Type sjj_C37C3.6 (PCR reagent)
Laboratory  NL
Date  2003-10-01
Strain  NL4256 rrf-3(pk1426)
Reference  Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...."
Cenix:36-a2
Adult Phenotypes  Larval Arrest-Late (L3/L4)
RNAi Reagent Name & Type Cenix:36-a2 (PCR reagent)
Delivery Method  Injection
Remark  early embryonic: No significant defects.
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
Gene Plot of C37C3.6 Browse using GBrowse
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