Ace View of C37C3.6 | |||||||
C37C3.6 Details | |||||||
Description | C37C3.6 encodes three isoforms of a large, novel multidomain glycoprotein orthologous to thrombospondin from Haemonchus contortus, papilin from D. melanogaster, and lacunin from Manduca sexta; the N-terminal region of C37C3.6 proteins have a domain set also found in the C-terminal region of ADAMTS matrix-associated metalloproteinases; C37C3.6 is generally required for normal cell arrangements, being required in embryos for viability and normal hypodermal enclosure, and in L1 larvae for normal excretory canal function. | ||||||
GO Terms | metalloendopeptidase activity (GO:0004222) ; extracellular matrix (GO:0031012) ; serine protease inhibitor activity (GO:0004867) ; peptidase activity (GO:0008233) | ||||||
Location | V:7829482..7845359 | ||||||
RNAi Phenotypes |
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External Links | |||||||
Associated RNAi Experiments | |||||||
JA:C37C3.6 | |||||||
Embryonic Phenotypes | Emb Penetrance 10 % | ||||||
Larval Phenotypes | Gro |
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Adult Phenotypes | Pvl Rup Stp brood size (6 out of 10) Unc |
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RNAi Reagent Name & Type | sjj_C37C3.6 (PCR reagent) | ||||||
Laboratory | JA | ||||||
Date | 2003-1-10 | ||||||
Reference | Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...." | ||||||
Simmer:C37C3.6 | |||||||
Larval Phenotypes | Lva |
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Adult Phenotypes | Unc |
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RNAi Reagent Name & Type | sjj_C37C3.6 (PCR reagent) | ||||||
Laboratory | NL | ||||||
Date | 2003-10-01 | ||||||
Strain | NL4256 rrf-3(pk1426) | ||||||
Reference | Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...." | ||||||
Cenix:36-a2 | |||||||
Adult Phenotypes | Larval Arrest-Late (L3/L4) |
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RNAi Reagent Name & Type | Cenix:36-a2 (PCR reagent) | ||||||
Delivery Method | Injection | ||||||
Remark | early embryonic: No significant defects. | ||||||
Laboratory | TH | ||||||
Date | 2005-3-24 | ||||||
Reference | Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...." | ||||||
Gene Plot of C37C3.6 | |||||||