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Gene/ORF C37F5.1 (lin-1) Ace View of C37F5.1
C37F5.1 Details Help
Description  lin-1 encodes an Ets-domain-containing transcription factor that is a member of the ETS gene family that includes human ELK1, 3, and 4 (OMIM:600247); LIN-1 functions as a general effector of MAP kinase-mediated signaling; when MAP kinase is inactive, LIN-1 forms a complex with LIN-31/WH that inhibits vulval cell fate specification; upon MAP kinase activation (vulval induction), LIN-1 is phosphorylated, dissociates from LIN-31, and becomes inactive, thus allowing for vulval development.
Homology Group (KOG)  Predicted transcription factor
GO Terms  regulation of cell fate (GO:0042659) ; negative regulation of vulval development (sensu Nematoda) (GO:0040027) ; transcription factor activity (GO:0003700) ; regulation of transcription, DNA-dependent (GO:0006355) ; nucleus (GO:0005634) ; DNA binding (GO:0003677)
Location   IV:2275463..2300750
RNAi Phenotypes
Adult Muv ; Muv ; Muv ; Pvl
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Details
Wild Type RNAi Experiments
JA:C37F5.1 WT
Cenix:122-c2 WT
Experiments with Non-Wild Phenotypes
Simmer:C37F5.1:Screen Muv ; Pvl
Simmer:C37F5.1:Repeat_a Muv
[cgc5655]:C37F5.1 Unclassified
Gene Plot of C37F5.1 Browse using GBrowse
Gene Map