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Gene/ORF C43E11.7 (ndx-7) Ace View of C43E11.7
C43E11.7 Details Help
Description  ndx-7 encodes a NUDIX hydrolase; by sequence comparison, NDX-7 is predicted to function as a pyrophosphatase, and is most closely related to the mouse RP2 protein that has unknown substrate specificity but is regulated transcriptionally by the presence of androgens; in C. elegans, loss of ndx-7 activity via RNA-mediated interference (RNAi) does not result in any obvious abnormalities, consistent with the proposed nonessential roles for Nudix proteins in eliminating potentially toxic nucleotide metabolites from cells and modulating levels of metabolic intermediates by shuttling them into alternative biochemical pathways.
Homology Group (KOG)  Predicted hydrolase RP2 (NUDIX/MutT superfamily)
Location   I:4238690..4243128
RNAi Phenotypes No phenotypes observed.
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Details
Cenix:159-e1
Adult Phenotypes  WT
RNAi Reagent Name & Type Cenix:159-e1 (PCR reagent)
Delivery Method  Injection
Remark  Wildtype result in all three tests.
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
JA:C43E11.7
Adult Phenotypes  WT
RNAi Reagent Name & Type sjj_C43E11.7 (PCR reagent)
Laboratory  JA
Date  2000-11-16
Reference  Fraser AG et al. (2000) Nature "Functional genomic analysis of C. elegans chromosome I by systematic RNA ...."
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