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Gene/ORF C44B11.3 (mec-12) Ace View of C44B11.3
C44B11.3 Details Help
Description  mec-12 encodes a novel C. elegans alpha-tubulin that is unique amongst C. elegans alpha tubulins in that it may be subject to post-translational acetylation; MEC-12 is required for normal mechanosensory response to gentle touch, and specifically for formation of the 15-protofilament microtubule bundle present in the touch receptor neurons; mec-12 interacts genetically with mec-5, which encodes a unique C. elegans collagen secreted by the hypodermis; MEC-12 is highly expressed in the touch neurons as well as in several other neurons that do not contains the microfilament bundle, such as the ventral cord motorneurons.
Homology Group (KOG)  Alpha tubulin
GO Terms  mechanosensory behavior (GO:0007638) ; microtubule-based process (GO:0007017) ; response to mechanical stimulus (GO:0009612) ; microtubule (GO:0005874) ; structural constituent of cytoskeleton (GO:0005200) ; structural molecule activity (GO:0005198) ; microtubule-based movement (GO:0007018) ; GTPase activity (GO:0003924) ; GTP binding (GO:0005525) ; protein polymerization (GO:0051258) ; protein complex (GO:0043234)
Location   III:3131166..3140077
RNAi Phenotypes No phenotypes observed.
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Details
Wild Type RNAi Experiments
Cenix:327-f7 WT
JA:C44B11.3 WT
TH:327F7 WT
Gene Plot of C44B11.3 Browse using GBrowse
Gene Map