Gene/ORF
C45G3.1 (tag-255)
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Ace View of C45G3.1
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C45G3.1 Details |
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Description |
The C45G3.1 gene encodes a protein, with one N-terminal calponin-like actin-binding domain and two IQ calmodulin-binding domains, that is likely to be required for spindle structure and function, and (indirectly) for neural function, based on its orthology to Drosophila ABNORMAL SPINDLE and on its joint sterile and uncoordinated RNAi phenotypes; C45G3.1 is also orthologous to human ASPM (OMIM:605481), which when mutated leads to primary microcephaly; C45G3.1 is required for embryonic and larval viability, germline maintenance, vulval morphogenesis, meiosis, and locomotion. |
Homology Group (KOG) |
Microtubule-associated protein Asp
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Location |
I:9221435..9226777 |
RNAi Phenotypes |
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External Links |
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Associated RNAi Experiments |
View Details
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Experiments with Non-Wild Phenotypes |
PF:GL1_3E9 |
Abnormal size of pronucleus ; Delayed P0 spindle rotation ; Emb ; Excessive blebbing ; Lva ; Multiple maternal pronuclei ; Multiple nuclei in 1, 2, or 4-cell embryos ; Polar bodies abnormal ; Pvl ; Stp |
Simmer:C45G3.1:Screen_A |
Emb ; Lva ; Pvl ; Rup ; Unc |
Simmer:C45G3.1:Screen_B |
Emb ; Gro ; Pvl ; Rup ; Unc |
JA:C45G3.1 |
Emb ; Mei ; Unc |
Cenix:10-g1 |
Chromosome Segregation (karyomeres) abnormal ; Emb |
Gene Plot of C45G3.1 |
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