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Gene/ORF C45G3.1 (tag-255) Ace View of C45G3.1
C45G3.1 Details Help
Description  The C45G3.1 gene encodes a protein, with one N-terminal calponin-like actin-binding domain and two IQ calmodulin-binding domains, that is likely to be required for spindle structure and function, and (indirectly) for neural function, based on its orthology to Drosophila ABNORMAL SPINDLE and on its joint sterile and uncoordinated RNAi phenotypes; C45G3.1 is also orthologous to human ASPM (OMIM:605481), which when mutated leads to primary microcephaly; C45G3.1 is required for embryonic and larval viability, germline maintenance, vulval morphogenesis, meiosis, and locomotion.
Homology Group (KOG)  Microtubule-associated protein Asp
Location   I:9221435..9226777
RNAi Phenotypes
Early_embryo Multiple maternal pronuclei ; Chromosome Segregation (karyomeres) abnormal ; Multiple nuclei in 1, 2, or 4-cell embryos ; Mei ; Delayed P0 spindle rotation ; Excessive blebbing ; Abnormal size of pronucleus ; Polar bodies abnormal
Larva Lva ; Lva ; Gro
Adult Pvl ; Pvl ; Pvl ; Rup ; Rup ; Unc ; Unc ; Unc ; Stp
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Details
Experiments with Non-Wild Phenotypes
PF:GL1_3E9 Abnormal size of pronucleus ; Delayed P0 spindle rotation ; Emb ; Excessive blebbing ; Lva ; Multiple maternal pronuclei ; Multiple nuclei in 1, 2, or 4-cell embryos ; Polar bodies abnormal ; Pvl ; Stp
Simmer:C45G3.1:Screen_A Emb ; Lva ; Pvl ; Rup ; Unc
Simmer:C45G3.1:Screen_B Emb ; Gro ; Pvl ; Rup ; Unc
JA:C45G3.1 Emb ; Mei ; Unc
Cenix:10-g1 Chromosome Segregation (karyomeres) abnormal ; Emb
Gene Plot of C45G3.1 Browse using GBrowse
Gene Map