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Gene/ORF C47D12.8 Ace View of C47D12.8
C47D12.8 Details Help
Description  C47D12.8 encodes an ortholog of the DNA repair protein XPF/ERCC4, which when mutated in humans leads to xeroderma pigmentosum (complementation group F; OMIM:133520); C47D12.8(RNAi) animals are hypersensitive to ultraviolet radiation, with increased germ cell apoptosis and embryonic lethality; C47D12.8 protein interacts with F10G8.7 (an ERCC1 ortholog) in yeast two-hybrid assays; C47D12.8 is expressed broadly in both embryonic and postembryonic animals, and is required for embryonic development; C47D12.8 is upregulated in dauers, and shares an operon with kel-1 and VF13D12L.3.
Homology Group (KOG)  Structure-specific endonuclease ERCC1-XPF, catalytic component XPF/ERCC4
GO Terms  nucleic acid binding (GO:0003676) ; nuclease activity (GO:0004518) ; DNA metabolism (GO:0006259)
Location   II:11695678..11705642
RNAi Phenotypes No phenotypes observed.
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Details
Cenix:200-h3
Adult Phenotypes  WT
RNAi Reagent Name & Type Cenix:200-h3 (PCR reagent)
Delivery Method  Injection
Remark  3/3 tests are wildtype.
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
JA:C47D12.8
Adult Phenotypes  WT
RNAi Reagent Name & Type sjj_C47D12.8 (PCR reagent)
Laboratory  JA
Date  2003-1-10
Reference  Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...."
Gene Plot of C47D12.8 Browse using GBrowse
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