Ace View of C47D12.8 | |
C47D12.8 Details | |
Description | C47D12.8 encodes an ortholog of the DNA repair protein XPF/ERCC4, which when mutated in humans leads to xeroderma pigmentosum (complementation group F; OMIM:133520); C47D12.8(RNAi) animals are hypersensitive to ultraviolet radiation, with increased germ cell apoptosis and embryonic lethality; C47D12.8 protein interacts with F10G8.7 (an ERCC1 ortholog) in yeast two-hybrid assays; C47D12.8 is expressed broadly in both embryonic and postembryonic animals, and is required for embryonic development; C47D12.8 is upregulated in dauers, and shares an operon with kel-1 and VF13D12L.3. |
Homology Group (KOG) | Structure-specific endonuclease ERCC1-XPF, catalytic component XPF/ERCC4 |
GO Terms | nucleic acid binding (GO:0003676) ; nuclease activity (GO:0004518) ; DNA metabolism (GO:0006259) |
Location | II:11695678..11705642 |
RNAi Phenotypes | No phenotypes observed. |
External Links | |
Associated RNAi Experiments | |
Cenix:200-h3 | |
Adult Phenotypes | WT |
RNAi Reagent Name & Type | Cenix:200-h3 (PCR reagent) |
Delivery Method | Injection |
Remark | 3/3 tests are wildtype. |
Laboratory | TH |
Date | 2005-3-24 |
Reference | Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...." |
JA:C47D12.8 | |
Adult Phenotypes | WT |
RNAi Reagent Name & Type | sjj_C47D12.8 (PCR reagent) |
Laboratory | JA |
Date | 2003-1-10 |
Reference | Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...." |
Gene Plot of C47D12.8 | |