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Gene/ORF C47E12.5 (uba-1) Ace View of C47E12.5
C47E12.5 Details Help
Description  uba-1 encodes a ubiquitin-activating enzyme orthologous to Saccharomyces cerevisiae UBA1 and human UBE1; UBA-1 is essential for embryogenesis and is required for germline development; by homology, UBA-1 is predicted to function in an ATP-dependent reaction that activates ubiquitin prior to its conjugation to proteins that will subsequently be degraded by the 26S proteasome; a uba-1 transcriptional reporter fusion is expressed in the larval intestine.
GO Terms  catalytic activity (GO:0003824) ; ubiquitin activating enzyme activity (GO:0004839) ; protein modification (GO:0006464) ; ubiquitin cycle (GO:0006512) ; ubiquitin-like activating enzyme activity (GO:0008642)
Location   IV:9989028..9995406
RNAi Phenotypes
Early_embryo Passage Through Meiosis defective
Adult Sck ; Sck ; Ste ; Ste ; Ste
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Details
Experiments with Non-Wild Phenotypes
Simmer:C47E12.5 Emb
JA:C47E12.5 Emb ; Sck ; Ste
Cenix:36-c2 Emb ; Passage Through Meiosis defective
Gene Plot of C47E12.5 Browse using GBrowse
Gene Map