Ace View of C47E8.5 | |||
C47E8.5 Details | |||
Description | daf-21 encodes a member of the Hsp90 family of molecular chaperones; DAF-21 activity is required for larval development, negative regulation of dauer larva formation, and a number of specific chemosensory behaviors, such as the response to chemicals and odorants detected by the ASE and AWC sensory neurons; a daf-21 sensory defect can be rescued by a cyclic GMP analogue, suggesting that, in regulating chemosensory behaviors, DAF-21 acts at a similar point as the DAF-11 guanylyl cyclase; down-regulation of daf-21 via RNAi results in a small but reproducible reduction in age-1 life span, suggesting that daf-21 is part of a chaperone network required for the extended life span seen in age-1 mutant animals. | ||
Homology Group (KOG) | Molecular chaperone (HSP90 family) |
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GO Terms | ATP binding (GO:0005524) ; unfolded protein binding (GO:0051082) ; protein folding (GO:0006457) | ||
Location | V:14687108..14691533 | ||
RNAi Phenotypes |
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External Links | |||
Associated RNAi Experiments | |||
Cenix:36-d2 | |||
Adult Phenotypes | Sterile F0/Fertility Problems Sterility/Impaired Fertility in F0 |
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RNAi Reagent Name & Type | Cenix:36-d2 (PCR reagent) | ||
Delivery Method | Injection | ||
Remark | early embryonic: Sterility/Impaired Fertility in F0 | ||
Laboratory | TH | ||
Date | 2005-3-24 | ||
Reference | Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...." | ||
Gene Plot of C47E8.5 | |||