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Gene/ORF C47E8.5 (daf-21) Ace View of C47E8.5
C47E8.5 Details Help
Description  daf-21 encodes a member of the Hsp90 family of molecular chaperones; DAF-21 activity is required for larval development, negative regulation of dauer larva formation, and a number of specific chemosensory behaviors, such as the response to chemicals and odorants detected by the ASE and AWC sensory neurons; a daf-21 sensory defect can be rescued by a cyclic GMP analogue, suggesting that, in regulating chemosensory behaviors, DAF-21 acts at a similar point as the DAF-11 guanylyl cyclase; down-regulation of daf-21 via RNAi results in a small but reproducible reduction in age-1 life span, suggesting that daf-21 is part of a chaperone network required for the extended life span seen in age-1 mutant animals.
Homology Group (KOG)  Molecular chaperone (HSP90 family)
GO Terms  ATP binding (GO:0005524) ; unfolded protein binding (GO:0051082) ; protein folding (GO:0006457)
Location   V:14687108..14691533
RNAi Phenotypes
Adult Sterile F0/Fertility Problems ; Sterility/Impaired Fertility in F0
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Details
Cenix:36-d2
Adult Phenotypes  Sterile F0/Fertility Problems
Sterility/Impaired Fertility in F0
RNAi Reagent Name & Type Cenix:36-d2 (PCR reagent)
Delivery Method  Injection
Remark  early embryonic: Sterility/Impaired Fertility in F0
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
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