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Gene/ORF C49H3.10 (imb-6) Ace View of C49H3.10
C49H3.10 Details Help
Description  imb-6 encodes an importin-beta-like protein orthologous to vertebrate Exportin-t, a specific mediator of tRNA export from the nucleus; IMB-6 is predicted to function by binding tRNAs directly in the presence of the RAN-1 GTPase and facilitating their nucleocytoplasmic transport; in C. elegans, loss of imb-6 function via RNA-mediated interference (RNAi) does not result in any obvious abnormalities.
Homology Group (KOG)  Nuclear mRNA export factor receptor LOS1/Exportin-t (importin beta superfamily)
GO Terms  tRNA-nucleus export (GO:0006409) ; nucleus (GO:0005634) ; cytoplasm (GO:0005737) ; tRNA binding (GO:0000049) ; binding (GO:0005488)
Location   IV:7915955..7924510
RNAi Phenotypes No phenotypes observed.
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Details
Cenix:59-a6
Adult Phenotypes  WT
RNAi Reagent Name & Type Cenix:59-a6 (PCR reagent)
Delivery Method  Injection
Remark  3/3 tests are wildtype
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
JA:C49H3.10
Adult Phenotypes  WT
RNAi Reagent Name & Type sjj_C49H3.10 (PCR reagent)
Laboratory  JA
Date  2003-1-10
Reference  Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...."
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