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Gene/ORF C50F4.11 (mdf-1) Ace View of C50F4.11
C50F4.11 Details Help
Description  mdf-1 encodes a coiled-coil domain-containing protein that is orthologous to the Saccharomyces cerevisiae mitotic spindle checkpoint protein Mad1p; consistent with a role as a checkpoint protein, MDF-1 is required in C. elegans for mitotic genome stability and hence, long-term survival and fertility; in vitro, MDF-1 interacts with MDF-2, the C. elegans Mad2p ortholog, and with IFY-1, a Securin homolog; the maternal effect lethality produced by an mdf-1 mutation can be suppressed by a mutation in fzy-1, which encodes the C. elegans Cdc20 homolog.
Location   V:9543967..9547210
RNAi Phenotypes
Adult Pvl ; Pvl ; Unc ; Unc
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Details
Experiments with Non-Wild Phenotypes
Simmer:C50F4.11 Pvl ; Unc
JA:C50F4.11 Unc
Cenix:165-a10 Pvl
Gene Plot of C50F4.11 Browse using GBrowse
Gene Map