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Gene/ORF C54G4.8 (cyc-1) Ace View of C54G4.8
C54G4.8 Details Help
Description  cyc-1 encodes a component of complex III ( cytochrome c reductase) required for normal ATP production; reduction of ATP production by cyc-1(RNAi) decreases growth rate and body size, slows behavior, and increases lifespan; cyc-1 encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial
Homology Group (KOG)  Cytochrome c1
GO Terms  electron transporter activity (GO:0005489) ; electron transport (GO:0006118) ; mitochondrial electron transport chain (GO:0005746) ; heme binding (GO:0020037)
Location   I:8022278..8024817
RNAi Phenotypes
Postembryonic WT_postembryonic_morphology
Larva Let ; Lva ; Lva ; Gro
Adult Pvl ; Ste
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Summary
JA:C54G4.8
Embryonic Phenotypes  Emb Penetrance 100 % Sle
Larval Phenotypes  Gro
RNAi Reagent Name & Type sjj_C54G4.8 (PCR reagent)
Laboratory  JA
Date  2000-11-16
Reference  Fraser AG et al. (2000) Nature "Functional genomic analysis of C. elegans chromosome I by systematic RNA ...."
Movies/Stacks/Images  /static/images/movie.gif /static/images/movie.gif
Simmer:C54G4.8:Screen_A
Embryonic Phenotypes  Emb Penetrance 90 %
Larval Phenotypes  Lva
RNAi Reagent Name & Type sjj_C54G4.8 (PCR reagent)
Laboratory  NL
Date  2003-10-01
Strain  NL4256 rrf-3(pk1426)
Reference  Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...."
Simmer:C54G4.8:Screen_B
Embryonic Phenotypes  Emb Penetrance 20 - 40 %
Larval Phenotypes  Lva
RNAi Reagent Name & Type sjj_C54G4.8 (PCR reagent)
Laboratory  NL
Date  2003-10-01
Strain  NL4256 rrf-3(pk1426)
Reference  Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...."
Cenix:19-d1
Embryonic Phenotypes  Emb Penetrance None reported
Adult Phenotypes  WT_postembryonic_morphology
RNAi Reagent Name & Type Cenix:19-d1 (PCR reagent)
Delivery Method  Injection
Remark  early embryonic: No significant defects.
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
Gene Plot of C54G4.8 Browse using GBrowse
Gene Map