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Gene/ORF C55B7.1 (glh-2) Ace View of C55B7.1
C55B7.1 Details Help
Description  glh-2 encodes a putative DEAD-box RNA helicase that contains six CCHC zinc fingers and is homologous to Drosophila VASA, a germ-line-specific, ATP-dependent, RNA helicase; at non-permissive temperatures, GLH-2 plays a role in germ-line development and fertility, specifically in regulating the normal extent of germ-line proliferation, oogenesis, and the production of functional sperm; GLH-2 activity may also be required for the wild-type morphology of P granules and for localization of several protein components, but not accumulation of P granule mRNA components; GLH-2 interacts in vitro with itself and with KGB-1, a JNK-like MAP kinase; GLH-2 is a constitutive P granule component and thus, with the exception of mature sperm, is expressed in germ cells at all stages of development; GLH-2 is cytoplasmic in oocytes and the early embryo, while perinuclear in all later developmental stages as well as in the distal and medial regions of the hermaphrodite gonad; GLH-2 is expressed at barely detectable levels in males.
Homology Group (KOG)  ATP-dependent RNA helicase
GO Terms  post-embryonic development (GO:0009791) ; germ-cell development (GO:0007281) ; RNA metabolism (GO:0016070) ; cytoplasm (GO:0005737) ; RNA helicase activity (GO:0003724) ; ATP binding (GO:0005524) ; ATP dependent helicase activity (GO:0008026) ; nucleic acid binding (GO:0003676) ; helicase activity (GO:0004386)
Location   I:6513622..6517905
RNAi Phenotypes No phenotypes observed.
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Details
Cenix:138-f3
Adult Phenotypes  WT
RNAi Reagent Name & Type Cenix:138-f3 (PCR reagent)
Delivery Method  Injection
Remark  Wildtype results in all three tests.
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
JA:C55B7.1
Adult Phenotypes  WT
RNAi Reagent Name & Type sjj_C55B7.1 (PCR reagent)
Laboratory  JA
Date  2000-11-16
Reference  Fraser AG et al. (2000) Nature "Functional genomic analysis of C. elegans chromosome I by systematic RNA ...."
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