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Gene/ORF C55B7.8 (dbr-1) Ace View of C55B7.8
C55B7.8 Details Help
Description  dbr-1 encodes a homolog of the RNA lariat-debranching enzyme; DBR-1 is predicted to function in RNA processing by hydrolyzing the 2'-5' phosphodiester bond at the branchpoint of excised lariat intron RNA, thus converting the introns into linear molecules that can subsequently be degraded by exonucleases; in C. elegans, DBR-1 activity is required for embryonic and germline development, as well as for normal rates of postembryonic growth; overexpression of C. elegans DBR-1 in Saccharomyces cerevisiae can complement the RNA processing defects of a dbr1 null mutant strain, restoring debranching activity and intron degradation to near wild-type levels.
Homology Group (KOG)  RNA lariat debranching enzyme
GO Terms  hydrolase activity, acting on ester bonds (GO:0016788) ; mRNA processing (GO:0006397) ; hydrolase activity (GO:0016787) ; structural constituent of ribosome (GO:0003735) ; protein biosynthesis (GO:0006412) ; intracellular (GO:0005622) ; ribosome (GO:0005840)
Location   I:6490320..6493129
RNAi Phenotypes
Larva Gro ; Gro ; Gro
Adult Pleiotropic ; Unc ; Stp
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Details
Wild Type RNAi Experiments
Cenix:146-c8 WT
JA:C55B7.8 WT
Experiments with Non-Wild Phenotypes
Simmer:C55B7.8:Screen_B Gro ; Unclassified
PF:GL1_6E10 Emb ; Gro ; Stp ; Pleiotropic
Simmer:C55B7.8:Screen_A Gro ; Unc ; Unclassified
Gene Plot of C55B7.8 Browse using GBrowse
Gene Map