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Gene/ORF D2013.5 (eat-3) Ace View of D2013.5
D2013.5 Details Help
Description  The eat-3 gene encodes a mitochondrial dynamin-related protein, closely related to bacterial dynamin-like proteins, that is orthologous to human OPA1 (OMIM:203740, mutated in autosomal dominant optic atrophy); EAT-3 is localized to the mitochondrial matrix and may play a role in regulating inner mitochondrial membrane morphology; EAT-3 is expressed in body wall muscle, intestine, and neurons, all tissues with high metabolic rates.
Homology Group (KOG)  Dynamin-like GTP binding protein
GO Terms  GTPase activity (GO:0003924) ; GTP binding (GO:0005525)
Location   II:9324388..9329969
RNAi Phenotypes
Postembryonic Pch
Larva Lva ; Lva ; Gro
Adult Dpy ; Bmd ; Ste ; Stp
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Summary
Cenix:201-g5
Adult Phenotypes  WT
RNAi Reagent Name & Type Cenix:201-g5 (PCR reagent)
Delivery Method  Injection
Remark  3/3 tests are wildtype.
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
JA:D2013.5
Embryonic Phenotypes  Emb Penetrance 80 %
Larval Phenotypes  Lva
Adult Phenotypes  Bmd
Dpy
Stp brood size (6 out of 10)
Adult Phenotypes  Pch
RNAi Reagent Name & Type sjj_D2013.5 (PCR reagent)
Laboratory  JA
Date  2003-1-10
Reference  Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...."
PF:GL1_7D10
Embryonic Phenotypes  Emb Penetrance 20 - 40 % Sle
Larval Phenotypes  Gro Observed in >=10% of progeny.
Adult Phenotypes  Ste
RNAi Reagent Name & Type sjj_D2013.5 (PCR reagent)
Delivery Method  Injection
Remark  PCR product contains flanking T7 promoter sequences
Laboratory  KK
Date  2002-11-19
Reference  Piano et al. (2002) Curr Biol "Gene Clustering Based on RNAi Phenotypes of Ovary-Enriched Genes in C. elegans"
Simmer:D2013.5
Embryonic Phenotypes  Emb Penetrance 20 - 40 %
Larval Phenotypes  Lva
RNAi Reagent Name & Type sjj_D2013.5 (PCR reagent)
Laboratory  NL
Date  2003-10-01
Strain  NL4256 rrf-3(pk1426)
Reference  Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...."
Gene Plot of D2013.5 Browse using GBrowse
Gene Map