Ace View of D2013.5 | |||||||
D2013.5 Details | |||||||
Description | The eat-3 gene encodes a mitochondrial dynamin-related protein, closely related to bacterial dynamin-like proteins, that is orthologous to human OPA1 (OMIM:203740, mutated in autosomal dominant optic atrophy); EAT-3 is localized to the mitochondrial matrix and may play a role in regulating inner mitochondrial membrane morphology; EAT-3 is expressed in body wall muscle, intestine, and neurons, all tissues with high metabolic rates. | ||||||
Homology Group (KOG) | Dynamin-like GTP binding protein |
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GO Terms | GTPase activity (GO:0003924) ; GTP binding (GO:0005525) | ||||||
Location | II:9324388..9329969 | ||||||
RNAi Phenotypes |
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External Links | |||||||
Associated RNAi Experiments | |||||||
Cenix:201-g5 | |||||||
Adult Phenotypes | WT |
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RNAi Reagent Name & Type | Cenix:201-g5 (PCR reagent) | ||||||
Delivery Method | Injection | ||||||
Remark | 3/3 tests are wildtype. | ||||||
Laboratory | TH | ||||||
Date | 2005-3-24 | ||||||
Reference | Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...." | ||||||
JA:D2013.5 | |||||||
Embryonic Phenotypes | Emb Penetrance 80 % | ||||||
Larval Phenotypes | Lva |
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Adult Phenotypes | Bmd Dpy Stp brood size (6 out of 10) |
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Adult Phenotypes | Pch |
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RNAi Reagent Name & Type | sjj_D2013.5 (PCR reagent) | ||||||
Laboratory | JA | ||||||
Date | 2003-1-10 | ||||||
Reference | Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...." | ||||||
PF:GL1_7D10 | |||||||
Embryonic Phenotypes | Emb Penetrance 20 - 40 % Sle | ||||||
Larval Phenotypes | Gro
Observed in >=10% of progeny. |
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Adult Phenotypes | Ste |
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RNAi Reagent Name & Type | sjj_D2013.5 (PCR reagent) | ||||||
Delivery Method | Injection | ||||||
Remark | PCR product contains flanking T7 promoter sequences | ||||||
Laboratory | KK | ||||||
Date | 2002-11-19 | ||||||
Reference | Piano et al. (2002) Curr Biol "Gene Clustering Based on RNAi Phenotypes of Ovary-Enriched Genes in C. elegans" | ||||||
Simmer:D2013.5 | |||||||
Embryonic Phenotypes | Emb Penetrance 20 - 40 % | ||||||
Larval Phenotypes | Lva |
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RNAi Reagent Name & Type | sjj_D2013.5 (PCR reagent) | ||||||
Laboratory | NL | ||||||
Date | 2003-10-01 | ||||||
Strain | NL4256 rrf-3(pk1426) | ||||||
Reference | Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...." | ||||||
Gene Plot of D2013.5 | |||||||