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Gene/ORF D2045.6 (cul-1) Ace View of D2045.6
D2045.6 Details Help
Description  cul-1 encodes a cullin, orthologous to Cdc53/Cul1 in S. cerevisiae and CUL-1 in humans (OMIM:603134), that is required both maternally and zygotically for developmentally programmed transitions from the G1 phase of the cell cycle to the GO phase or the apoptotic pathway, and that is probably also required for normally slow G1-to-S phase progression; CUL-1 physically interacts with eight Skp1-related proteins (SKR-1, -2, -3, -4, -7, -8, -9, and -10).
Homology Group (KOG)  Cullins
GO Terms  embryonic development (sensu Animalia) (GO:0009792) ; larval development (sensu Nematoda) (GO:0002119) ; negative regulation of mitotic cell cycle (GO:0045930) ; positive regulation of cell size (GO:0045793) ; regulation of cell division (GO:0051302) ; reproduction (GO:0000003) ; cytosol (GO:0005829) ; cell cycle (GO:0007049)
Location   III:10470718..10475881
RNAi Phenotypes
Postembryonic WT_postembryonic_morphology
Larva Lva
Adult Lon
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Details
Experiments with Non-Wild Phenotypes
Cenix:320-d5 Emb ; WT_postembryonic_morphology
Simmer:D2045.6 Emb
JA:D2045.6 Emb ; Lon
TH:320D5 Emb
Gene Plot of D2045.6 Browse using GBrowse
Gene Map