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Gene/ORF D2085.1 (pyr-1) Ace View of D2085.1
D2085.1 Details Help
Description  pyr-1 is orthologous to the human gene CARBAMYL PHOSPHATE SYNTHETASE I (CPS1, which when mutated leads to hyperammonemia (OMIM:237300); PYR-1 protein is predicted to be mitochondrial with 68% accuracy.
Homology Group (KOG)  Multifunctional pyrimidine synthesis protein CAD (includes carbamoyl-phophate synthetase, aspartate transcarbamylase, and glutamine amidotransferase)
GO Terms  hydrolase activity (GO:0016787) ; catalytic activity (GO:0003824) ; biosynthesis (GO:0009058) ; amino acid binding (GO:0016597) ; carboxyl- and carbamoyltransferase activity (GO:0016743) ; amino acid metabolism (GO:0006520) ; aspartate carbamoyltransferase activity (GO:0004070) ; 'de novo' pyrimidine base biosynthesis (GO:0006207) ; carbamoyl-phosphate synthase activity (GO:0004086) ; nitrogen metabolism (GO:0006807) ; ATP binding (GO:0005524) ; arginine biosynthesis (GO:0006526) ; pyrimidine base biosynthesis (GO:0019856) ; cytoplasm (GO:0005737) ; ligase activity (GO:0016874) ; metabolism (GO:0008152) ; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides (GO:0016812) ; glutamine metabolism (GO:0006541)
Location   II:8650659..8659133
RNAi Phenotypes
Larva Mlt ; Lvl ; Gro
Adult Unc
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Details
Adult Phenotypes  WT
RNAi Reagent Name & Type Cenix:138-a5 (PCR reagent)
Delivery Method  Injection
Remark  3/3 tests are wt.
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
Embryonic Phenotypes  Emb Penetrance 40 %
Larval Phenotypes  Gro
Adult Phenotypes  Unc
RNAi Reagent Name & Type sjj_D2085.1 (PCR reagent)
Laboratory  JA
Date  2003-1-10
Reference  Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...."
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