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Gene/ORF D2096.4 (sqv-1) Ace View of D2096.4
D2096.4 Details Help
Description  sqv-1 encodes a UDP-glucuronic acid decarboxylase, biochemically active in vitro, that is required for cytokinesis of one-cell embryos and for vulval morphogenesis; SQV-1 is coexpressed with the nucleotide-sugar transporter homolog SQV-7 in in the vulva and in oocytes; SQV-1 colocalizes with SQV-5 and SQV-7 to punctate foci (probably the Golgi apparatus) in the cytoplasm of the vulva, the uterus and oocytes, within which SQV-1 may act to promote the biosynthesis of chondroitin glycosaminoglycans; the common requirement for SQV-1 in both cytokinesis and morphogenesis may be to promote filling an extracellular space with hygroscopic proteoglycans (either in the eggshell, or underneath the L4 cuticle), which in turn may cause the space to fill with fluid.
Homology Group (KOG)  dTDP-glucose 4-6-dehydratase/UDP-glucuronic acid decarboxylase
GO Terms  catalytic activity (GO:0003824) ; NAD binding (GO:0051287) ; nucleotide-sugar metabolism (GO:0009225)
Location   IV:8360669..8363719
RNAi Phenotypes No phenotypes observed.
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Details
Cenix:55-e6
Adult Phenotypes  WT
RNAi Reagent Name & Type Cenix:55-e6 (PCR reagent)
Delivery Method  Injection
Remark  3/3 tests are wildtype.
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
JA:D2096.4
Adult Phenotypes  WT
RNAi Reagent Name & Type sjj_D2096.4 (PCR reagent)
Laboratory  JA
Date  2003-1-10
Reference  Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...."
Gene Plot of D2096.4 Browse using GBrowse
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