Ace View of D2096.4 | |
D2096.4 Details | |
Description | sqv-1 encodes a UDP-glucuronic acid decarboxylase, biochemically active in vitro, that is required for cytokinesis of one-cell embryos and for vulval morphogenesis; SQV-1 is coexpressed with the nucleotide-sugar transporter homolog SQV-7 in in the vulva and in oocytes; SQV-1 colocalizes with SQV-5 and SQV-7 to punctate foci (probably the Golgi apparatus) in the cytoplasm of the vulva, the uterus and oocytes, within which SQV-1 may act to promote the biosynthesis of chondroitin glycosaminoglycans; the common requirement for SQV-1 in both cytokinesis and morphogenesis may be to promote filling an extracellular space with hygroscopic proteoglycans (either in the eggshell, or underneath the L4 cuticle), which in turn may cause the space to fill with fluid. |
Homology Group (KOG) | dTDP-glucose 4-6-dehydratase/UDP-glucuronic acid decarboxylase |
GO Terms | catalytic activity (GO:0003824) ; NAD binding (GO:0051287) ; nucleotide-sugar metabolism (GO:0009225) |
Location | IV:8360669..8363719 |
RNAi Phenotypes | No phenotypes observed. |
External Links | |
Associated RNAi Experiments | |
Cenix:55-e6 | |
Adult Phenotypes | WT |
RNAi Reagent Name & Type | Cenix:55-e6 (PCR reagent) |
Delivery Method | Injection |
Remark | 3/3 tests are wildtype. |
Laboratory | TH |
Date | 2005-3-24 |
Reference | Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...." |
JA:D2096.4 | |
Adult Phenotypes | WT |
RNAi Reagent Name & Type | sjj_D2096.4 (PCR reagent) |
Laboratory | JA |
Date | 2003-1-10 |
Reference | Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...." |
Gene Plot of D2096.4 | |