ORF Card Page


Gene/ORF DH11.3 (pgp-11)	Ace View of DH11.3
DH11.3 Details
Description	pgp-11 encodes a transmembrane protein that is a member of the P-glycoprotein subclass of the ATP-binding cassette (ABC) transporter superfamily; by homology, PGP-11 is predicted to function as an ATP-dependent efflux pump that protects C. elegans by exporting exogenous toxins; however, as loss of pgp-11 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of PGP-11 in C. elegans development and/or behavior is not yet known.
Homology Group (KOG)	Multidrug/pheromone exporter, ABC superfamily
GO Terms	nucleotide binding (GO:0000166) ; nucleoside triphosphatase activity (GO:0017111) ; ATP binding (GO:0005524) ; ATPase activity, coupled to transmembrane movement of substances (GO:0042626) ; transport (GO:0006810) ; integral to membrane (GO:0016021) ; ATPase activity (GO:0016887)
Location	II:7995111..8003476
RNAi Phenotypes	No phenotypes observed.
External Links
Associated RNAi Experiments	View Details
Cenix:246-e5
Adult Phenotypes	WT
RNAi Reagent Name & Type	Cenix:246-e5 (PCR reagent)
Delivery Method	Injection
Remark	Overall wildtype results.
Laboratory	TH
Date	2005-3-24
Reference	Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
JA:DH11.3
Adult Phenotypes	WT
RNAi Reagent Name & Type	sjj_DH11.3 (PCR reagent)
Laboratory	JA
Date	2003-1-10
Reference	Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...."
Gene Plot of DH11.3	*Browse using GBrowse*