ORF Card Page


Gene/ORF E03G2.3 (mec-5)	Ace View of E03G2.3
E03G2.3 Details
Description	mec-5 encodes a collagen unique in the number of Gly-X-Y repeats and in the composition of amino acids surrounding these repeats; MEC-5 is required for normal mechanosensory response to gentle touch and for the proper functioning of the touch receptor neurons; mec-5 interacts genetically with mec-4 and mec-10 which encode degenerins (ion channels) expressed in the touch neurons, mec-9, which encodes a protein containing EGF-like and Kunitz/protease inhibitor domains secreted by the touch neurons, and mec-12, which encodes an alpha-tubulin expressed in the touch neurons; these genetic interactions suggest that MEC-5 may play a role in anchoring the degenerin complex to the extracellular matrix; MEC-5 is produced and secreted by hypodermal cells.
GO Terms	mechanosensory behavior (GO:0007638) ; response to mechanical stimulus (GO:0009612) ; extracellular matrix (GO:0005578) ; extracellular matrix structural constituent (GO:0005201) ; phosphate transport (GO:0006817) ; cytoplasm (GO:0005737)
Location	X:15943526..15949270
RNAi Phenotypes	No phenotypes observed.
External Links
Associated RNAi Experiments	View Details
Cenix:121-f12
Adult Phenotypes	WT
RNAi Reagent Name & Type	Cenix:121-f12 (PCR reagent)
Delivery Method	Injection
Remark	Wildtype results in all three tests.
Laboratory	TH
Date	2005-3-24
Reference	Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
JA:E03G2.3
Adult Phenotypes	WT
RNAi Reagent Name & Type	sjj_E03G2.3 (PCR reagent)
Laboratory	JA
Date	2003-1-10
Reference	Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...."
Gene Plot of E03G2.3	*Browse using GBrowse*