ORF Card Page

Gene/ORF F01G12.5 (let-2)

F01G12.5 Details

Description

let-2 encodes an alpha-2 type IV collagen, probably most closely equivalent to the human gene COL4A2 (OMIM:120090) on the basis of biological function; LET-2 is required for embryonic development and is a component of the basement membrane between muscle and hypodermis; LET-2 interacts with UNC-105, a mechanosensory ion channel of the degenerin ion channel superfamily that is expressed in muscle and required for normal growth, muscle contraction, and muscle organization.

Homology Group (KOG)

Collagens (type IV and type XIII), and related proteins

GO Terms

phosphate transport (GO:0006817) ; cytoplasm (GO:0005737) ; extracellular matrix structural constituent (GO:0005201) ; collagen (GO:0005581)

Location

X:16380115..16389642

RNAi Phenotypes