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Gene/ORF F01G12.5 (let-2) Ace View of F01G12.5
F01G12.5 Details Help
Description  let-2 encodes an alpha-2 type IV collagen, probably most closely equivalent to the human gene COL4A2 (OMIM:120090) on the basis of biological function; LET-2 is required for embryonic development and is a component of the basement membrane between muscle and hypodermis; LET-2 interacts with UNC-105, a mechanosensory ion channel of the degenerin ion channel superfamily that is expressed in muscle and required for normal growth, muscle contraction, and muscle organization.
Homology Group (KOG)  Collagens (type IV and type XIII), and related proteins
GO Terms  phosphate transport (GO:0006817) ; cytoplasm (GO:0005737) ; extracellular matrix structural constituent (GO:0005201) ; collagen (GO:0005581)
Location   X:16380115..16389642
RNAi Phenotypes
Postembryonic WT_postembryonic_morphology
Larva Lva ; Lva
Adult Dpy ; Dpy ; Bmd ; Bmd ; Ste ; Unc ; Unc ; Unc
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Summary
JA:F01G12.5a
Adult Phenotypes  WT
RNAi Reagent Name & Type sjj_F01G12.5a (PCR reagent)
Laboratory  JA
Date  2003-1-10
Reference  Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...."
Simmer:F01G12.5a:Repeat_a
Adult Phenotypes  Unc
RNAi Reagent Name & Type sjj_F01G12.5a (PCR reagent)
Laboratory  NL
Date  2003-10-01
Strain  NL4256 rrf-3(pk1426)
Reference  Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...."
Simmer:F01G12.5a:Screen
Larval Phenotypes  Lva
Adult Phenotypes  Unc
RNAi Reagent Name & Type sjj_F01G12.5a (PCR reagent)
Laboratory  NL
Date  2003-10-01
Strain  NL4256 rrf-3(pk1426)
Reference  Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...."
Cenix:71-f6
Embryonic Phenotypes  Emb Penetrance None reported
Adult Phenotypes  WT_postembryonic_morphology
RNAi Reagent Name & Type Cenix:71-f6 (PCR reagent)
Delivery Method  Injection
Remark  early embryonic: No significant defects.
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
Gene Plot of F01G12.5 Browse using GBrowse
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