Gene/ORF
F10B5.6 (emb-27)
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Ace View of F10B5.6
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F10B5.6 Details |
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Description |
emb-27 encodes a tetratricopeptide repeat (TPR)-containing protein that is the C. elegans ortholog of the anaphase-promoting complex (APC) subunit APC-6 (CDC16); required maternally and paternally, EMB-27 activity is essential for proper execution of the metaphase-to-anaphase transition during meiosis (both oogenesis and spermatogenesis) and mitosis (during germline proliferation); EMB-27 activity is also critical for embryonic anterior-posterior (A-P) axis formation, production of the secreted eggshell, and normal vulval development; in establishing the embryonic A-P axis, EMB-27 likely acts upstream of the separin protease to ensure proper localization of PAR-3 and PAR-2 to the anterior and posterior cortices, respectively. |
Homology Group (KOG) |
Anaphase-promoting complex (APC), Cdc16 subunit
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GO Terms |
binding
(GO:0005488) |
Location |
II:8159386..8162495 |
RNAi Phenotypes |
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External Links |
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Associated RNAi Experiments |
View Details
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Experiments with Non-Wild Phenotypes |
Simmer:F10B5.6 |
Emb |
PF:GL1_4G9 |
Catastrophic one-cell arrest ; Emb ; Osmotically/ pressure sensitive ; Stp ; No developing embryos seen 48 hours after dsRNA injection ; Reduced fecundity of injected worm ; Ste |
JA:F10B5.6 |
Emb ; Pvl |
Cenix:208-a6 |
Emb ; Passage Through Meiosis defective |
Gene Plot of F10B5.6 |
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