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Gene/ORF F10B5.6 (emb-27) Ace View of F10B5.6
F10B5.6 Details Help
Description  emb-27 encodes a tetratricopeptide repeat (TPR)-containing protein that is the C. elegans ortholog of the anaphase-promoting complex (APC) subunit APC-6 (CDC16); required maternally and paternally, EMB-27 activity is essential for proper execution of the metaphase-to-anaphase transition during meiosis (both oogenesis and spermatogenesis) and mitosis (during germline proliferation); EMB-27 activity is also critical for embryonic anterior-posterior (A-P) axis formation, production of the secreted eggshell, and normal vulval development; in establishing the embryonic A-P axis, EMB-27 likely acts upstream of the separin protease to ensure proper localization of PAR-3 and PAR-2 to the anterior and posterior cortices, respectively.
Homology Group (KOG)  Anaphase-promoting complex (APC), Cdc16 subunit
GO Terms  binding (GO:0005488)
Location   II:8159386..8162495
RNAi Phenotypes
Early_embryo Catastrophic one-cell arrest ; Osmotically/ pressure sensitive ; Passage Through Meiosis defective
Adult Reduced fecundity of injected worm ; Pvl ; Ste ; No developing embryos seen 48 hours after dsRNA injection ; Stp ; Stp
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Details
Experiments with Non-Wild Phenotypes
Simmer:F10B5.6 Emb
PF:GL1_4G9 Catastrophic one-cell arrest ; Emb ; Osmotically/ pressure sensitive ; Stp ; No developing embryos seen 48 hours after dsRNA injection ; Reduced fecundity of injected worm ; Ste
JA:F10B5.6 Emb ; Pvl
Cenix:208-a6 Emb ; Passage Through Meiosis defective
Gene Plot of F10B5.6 Browse using GBrowse
Gene Map