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Gene/ORF F10E9.6 (mig-10) Ace View of F10E9.6
F10E9.6 Details Help
Description  mig-10 encodes a protein containing a pleckstrin homology domain and a proline-rich region, and is similar to the SH2-domain containing adapter proteins Grb7 and Grb10 which are involved in receptor tyrosine kinase-mediated signal transduction; MIG-10 is likely required for signal transduction during cell migration, as it is required non-cell autonomously for excretory canal development and anterior-posterior migrations of the embryonic neurons ALM, CAN, and HSN; mig-10 mutations appear to interact genetically with mutations in all three C. elegans rac genes, ced-10, mig-2, and rac-2, suggesting partial redundancy during neuronal migration and excretory canal outgrowth; MIG-10 is expressed in many embryonic cells and in four cells in the adult head.
Homology Group (KOG)  Growth factor receptor-bound proteins (GRB7, GRB10, GRB14)
GO Terms  vulval development (sensu Nematoda) (GO:0040025) ; tail morphogenesis (GO:0035121) ; oviposition (GO:0018991) ; locomotion (GO:0040011) ; regulation of cell migration (GO:0030334) ; mesoderm cell migration (GO:0008078) ; neuronal migration (GO:0001764) ; signal transduction (GO:0007165)
Location   III:8278623..8306129
RNAi Phenotypes
Larva Gro
Adult Egl ; Egl ; Unc ; Unc
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Details
Wild Type RNAi Experiments
JA:F10E9.9 WT
TH:310A1 WT
TH:305H11 WT
Cenix:310-b1 WT
JA:F09G8.1 WT
Cenix:314-c10 WT
Cenix:310-a1 WT
Cenix:302-a12 WT
JA:F10E9.6 WT
TH:314C10 WT
Cenix:305-h11 WT
TH:302A12 WT
TH:310B1 WT
Experiments with Non-Wild Phenotypes
Simmer:F10E9.6:Repeat_a Egl ; Unc
Simmer:F10E9.6:Screen Egl ; Unc
Simmer:F10E9.7 Emb ; Gro
Gene Plot of F10E9.6 Browse using GBrowse
Gene Map