Ace View of F10E9.6 | |||||
F10E9.6 Details | |||||
Description | mig-10 encodes a protein containing a pleckstrin homology domain and a proline-rich region, and is similar to the SH2-domain containing adapter proteins Grb7 and Grb10 which are involved in receptor tyrosine kinase-mediated signal transduction; MIG-10 is likely required for signal transduction during cell migration, as it is required non-cell autonomously for excretory canal development and anterior-posterior migrations of the embryonic neurons ALM, CAN, and HSN; mig-10 mutations appear to interact genetically with mutations in all three C. elegans rac genes, ced-10, mig-2, and rac-2, suggesting partial redundancy during neuronal migration and excretory canal outgrowth; MIG-10 is expressed in many embryonic cells and in four cells in the adult head. | ||||
Homology Group (KOG) | Growth factor receptor-bound proteins (GRB7, GRB10, GRB14) |
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GO Terms | vulval development (sensu Nematoda) (GO:0040025) ; tail morphogenesis (GO:0035121) ; oviposition (GO:0018991) ; locomotion (GO:0040011) ; regulation of cell migration (GO:0030334) ; mesoderm cell migration (GO:0008078) ; neuronal migration (GO:0001764) ; signal transduction (GO:0007165) | ||||
Location | III:8278623..8306129 | ||||
RNAi Phenotypes |
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External Links | |||||
Associated RNAi Experiments | |||||
Cenix:302-a12 | |||||
Adult Phenotypes | WT |
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RNAi Reagent Name & Type | Cenix:302-a12 (PCR reagent) | ||||
Delivery Method | Injection | ||||
Remark | wild type | ||||
Laboratory | TH | ||||
Date | 2005-3-24 | ||||
Reference | Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...." | ||||
Cenix:305-h11 | |||||
Adult Phenotypes | WT |
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RNAi Reagent Name & Type | Cenix:305-h11 (PCR reagent) | ||||
Delivery Method | Injection | ||||
Remark | wild type | ||||
Laboratory | TH | ||||
Date | 2005-3-24 | ||||
Reference | Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...." | ||||
Cenix:310-a1 | |||||
Adult Phenotypes | WT |
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RNAi Reagent Name & Type | Cenix:310-a1 (PCR reagent) | ||||
Delivery Method | Injection | ||||
Remark | wild type | ||||
Laboratory | TH | ||||
Date | 2005-3-24 | ||||
Reference | Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...." | ||||
Cenix:310-b1 | |||||
Adult Phenotypes | WT |
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RNAi Reagent Name & Type | Cenix:310-b1 (PCR reagent) | ||||
Delivery Method | Injection | ||||
Remark | wild type | ||||
Laboratory | TH | ||||
Date | 2005-3-24 | ||||
Reference | Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...." | ||||
Cenix:314-c10 | |||||
Adult Phenotypes | WT |
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RNAi Reagent Name & Type | Cenix:314-c10 (PCR reagent) | ||||
Delivery Method | Injection | ||||
Remark | wild type | ||||
Laboratory | TH | ||||
Date | 2005-3-24 | ||||
Reference | Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...." | ||||
JA:F09G8.1 | |||||
Adult Phenotypes | WT |
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RNAi Reagent Name & Type | sjj_F09G8.1 (PCR reagent) | ||||
Laboratory | JA | ||||
Date | 2003-1-10 | ||||
Reference | Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...." | ||||
JA:F10E9.6 | |||||
Adult Phenotypes | WT |
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RNAi Reagent Name & Type | sjj_F10E9.6 (PCR reagent) | ||||
Laboratory | JA | ||||
Date | 2003-1-10 | ||||
Reference | Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...." | ||||
JA:F10E9.9 | |||||
Adult Phenotypes | WT |
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RNAi Reagent Name & Type | sjj_F10E9.9 (PCR reagent) | ||||
Laboratory | JA | ||||
Date | 2003-1-10 | ||||
Reference | Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...." | ||||
Simmer:F10E9.6:Repeat_a | |||||
Adult Phenotypes | Egl Unc |
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RNAi Reagent Name & Type | sjj_F10E9.6 (PCR reagent) | ||||
Laboratory | NL | ||||
Date | 2003-10-01 | ||||
Strain | NL4256 rrf-3(pk1426) | ||||
Reference | Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...." | ||||
Simmer:F10E9.6:Screen | |||||
Adult Phenotypes | Egl Unc |
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RNAi Reagent Name & Type | sjj_F10E9.6 (PCR reagent) | ||||
Laboratory | NL | ||||
Date | 2003-10-01 | ||||
Strain | NL4256 rrf-3(pk1426) | ||||
Reference | Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...." | ||||
Simmer:F10E9.7 | |||||
Embryonic Phenotypes | Emb Penetrance 20 - 40 % | ||||
Larval Phenotypes | Gro |
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RNAi Reagent Name & Type | sjj_F10E9.7 (PCR reagent) | ||||
Laboratory | NL | ||||
Date | 2003-10-01 | ||||
Strain | NL4256 rrf-3(pk1426) | ||||
Reference | Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...." | ||||
TH:302A12 | |||||
Adult Phenotypes | WTDIC phenotype -- Embryonic development normal |
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RNAi Reagent Name & Type | TH:302A12 (PCR reagent) | ||||
Delivery Method | Injection | ||||
Laboratory | TH | ||||
Date | 2000-11-16 | ||||
Reference | Gonczy P et al. (2000) Nature "Functional genomic analysis of cell division in C. elegans using RNAi of genes on ...." | ||||
TH:305H11 | |||||
Adult Phenotypes | WTDIC phenotype -- Embryonic development normal |
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RNAi Reagent Name & Type | TH:305H11 (PCR reagent) | ||||
Delivery Method | Injection | ||||
Laboratory | TH | ||||
Date | 2000-11-16 | ||||
Reference | Gonczy P et al. (2000) Nature "Functional genomic analysis of cell division in C. elegans using RNAi of genes on ...." | ||||
TH:310A1 | |||||
Adult Phenotypes | WTDIC phenotype -- Embryonic development normal |
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RNAi Reagent Name & Type | TH:310A1 (PCR reagent) | ||||
Delivery Method | Injection | ||||
Laboratory | TH | ||||
Date | 2000-11-16 | ||||
Reference | Gonczy P et al. (2000) Nature "Functional genomic analysis of cell division in C. elegans using RNAi of genes on ...." | ||||
TH:310B1 | |||||
Adult Phenotypes | WTDIC phenotype -- Embryonic development normal |
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RNAi Reagent Name & Type | TH:310B1 (PCR reagent) | ||||
Delivery Method | Injection | ||||
Laboratory | TH | ||||
Date | 2000-11-16 | ||||
Reference | Gonczy P et al. (2000) Nature "Functional genomic analysis of cell division in C. elegans using RNAi of genes on ...." | ||||
TH:314C10 | |||||
Adult Phenotypes | WTDIC phenotype -- Embryonic development normal |
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RNAi Reagent Name & Type | TH:314C10 (PCR reagent) | ||||
Delivery Method | Injection | ||||
Laboratory | TH | ||||
Date | 2000-11-16 | ||||
Reference | Gonczy P et al. (2000) Nature "Functional genomic analysis of cell division in C. elegans using RNAi of genes on ...." | ||||
Gene Plot of F10E9.6 | |||||