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Gene/ORF F11C3.3 (unc-54) Ace View of F11C3.3
F11C3.3 Details Help
Description  unc-54 encodes a muscle myosin class II heavy chain (MHC B); UNC-54 is the major myosin heavy chain expressed in C. elegans and is required for locomotion and egg-laying; in vivo and in vitro, UNC-54 interacts with ITR-1, an IP3 receptor, and this interaction may provide a link between calcium signaling and the muscle cytoskeleton; UNC-54 is a thick filament component that is expressed in multiple muscle cell classes including body wall, intestinal, anal depressor, and sphincter muscles as well as sex-specific muscles that develop postembryonically.
Homology Group (KOG)  Myosin class II heavy chain
GO Terms  motor activity (GO:0003774) ; ATP binding (GO:0005524) ; myosin (GO:0016459)
Location   I:14852090..14863924
RNAi Phenotypes
Larva Lva
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Details
Adult Phenotypes  WT
RNAi Reagent Name & Type Cenix:19-c11 (PCR reagent)
Delivery Method  Injection
Remark  early embryonic: Only low reproducible defects found in two other experiments.
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
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