Gene/ORF
F11C3.3 (unc-54)
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Ace View of F11C3.3
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F11C3.3 Details |
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Description |
unc-54 encodes a muscle myosin class II heavy chain (MHC B); UNC-54 is the major myosin heavy chain expressed in C. elegans and is required for locomotion and egg-laying; in vivo and in vitro, UNC-54 interacts with ITR-1, an IP3 receptor, and this interaction may provide a link between calcium signaling and the muscle cytoskeleton; UNC-54 is a thick filament component that is expressed in multiple muscle cell classes including body wall, intestinal, anal depressor, and sphincter muscles as well as sex-specific muscles that develop postembryonically. |
Homology Group (KOG) |
Myosin class II heavy chain
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GO Terms |
motor activity
(GO:0003774) ; ATP binding
(GO:0005524) ; myosin
(GO:0016459) |
Location |
I:14852090..14863924 |
RNAi Phenotypes |
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External Links |
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Associated RNAi Experiments |
View Details
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Cenix:19-c11
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Adult Phenotypes |
WT
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RNAi Reagent Name & Type |
Cenix:19-c11 (PCR reagent) |
Delivery Method |
Injection |
Remark |
early embryonic: Only low reproducible defects found in two other experiments. |
Laboratory |
TH |
Date |
2005-3-24 |
Reference |
Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...." |
Gene Plot of F11C3.3 |
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