Go to RNAiDB Home Adult Wild-type C. elegans Movie Wild-type C. elegans Movie Wild-type C. elegans Movie Wild-type C. elegans Movie
Link to F18A1.5.1Link to F18A1.5.2RNAiRNAiRNAiRNAiRNAiRNAi ReagentRNAi ReagentRNAi ReagentgeneMap
Gene/ORF F18A1.5 Ace View of F18A1.5
F18A1.5 Details Help
Description  F18A1.5 encodes the C. elegans ortholog of the replication protein A (RPA) large subunit; by homology, the F18A1.5 gene product is predicted to function as a DNA binding and oligonucleotide oligosaccharide binding (OB) protein that is required for DNA replication, repair, and recombination; large-scale RNAi screens indicate that the product of F18A1.5 is essential for embryonic development, and that in yeast two-hybrid assays interacts with the product of M04F3.1, the RPA medium subunit; in situ hybridization studies indicate that F18A1.5 transcripts are expressed in germ cells.
Homology Group (KOG)  Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins
GO Terms  nucleic acid binding (GO:0003676) ; DNA binding (GO:0003677) ; DNA replication (GO:0006260) ; nucleus (GO:0005634)
Location   II:7664096..7667426
RNAi Phenotypes
Early_embryo Exaggerated asynchrony ; Sister Chromatid Separation abnormal (Cross-eyed) ; Multiple maternal pronuclei ; Aberrant nuclear reassembly ; Ectopic cleavage furrows ; Slow cell cycle ; Excessive blebbing ; Abnormal size of pronucleus ; Aberrant cell-cell contacts at the four-cell stage
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Details
Experiments with Non-Wild Phenotypes
JA:F18A1.5 Emb
Simmer:F18A1.5 Emb
PF:GL1_5G7 Aberrant cell-cell contacts at the four-cell stage ; Aberrant nuclear reassembly ; Abnormal size of pronucleus ; Ectopic cleavage furrows ; Emb ; Exaggerated asynchrony ; Excessive blebbing ; Multiple maternal pronuclei ; Slow cell cycle
Cenix:204-f5 Emb ; Sister Chromatid Separation abnormal (Cross-eyed)
Gene Plot of F18A1.5 Browse using GBrowse
Gene Map