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Gene/ORF F18A12.8 Ace View of F18A12.8
F18A12.8 Details Help
Description  F18A12.8 encodes two isoforms of a neprilysin; neprilysins are thermolysin-like zinc metallopeptidases, found on the outer surface of animal cells, that negatively regulate small signalling peptides (e.g., enkephalin, tachykinin, insulin, and natriuretic peptides) by cleaving them; F18A12.8A is closely paralogous to ZK20.6, and orthologous to CG9761 in Drosophila melanogaster; F18A12.8 is homologous, and possibly orthologous, to human ECE1 (OMIM:600423; mutation leads to Hirschsprung disease, cardiac defects, and autonomic dysfunction); more generally, F18A12.8A falls into a group of proteins that includes the classical neprilysins found in mammals (e.g., PEX [OMIM:307800] and the enkephalin cleaving enzymes).
GO Terms  metallopeptidase activity (GO:0008237) ; zinc ion binding (GO:0008270) ; proteolysis and peptidolysis (GO:0006508) ; neprilysin activity (GO:0004245) ; membrane (GO:0016020)
Location   II:3420261..3425927
RNAi Phenotypes No phenotypes observed.
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Details
Cenix:243-c3
Adult Phenotypes  WT
RNAi Reagent Name & Type Cenix:243-c3 (PCR reagent)
Delivery Method  Injection
Remark  Wildtype results in all three tests.
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
JA:F18A12.8
Adult Phenotypes  WT
RNAi Reagent Name & Type sjj_F18A12.8 (PCR reagent)
Laboratory  JA
Date  2003-1-10
Reference  Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...."
Gene Plot of F18A12.8 Browse using GBrowse
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