Ace View of F18A12.8 | |
F18A12.8 Details | |
Description | F18A12.8 encodes two isoforms of a neprilysin; neprilysins are thermolysin-like zinc metallopeptidases, found on the outer surface of animal cells, that negatively regulate small signalling peptides (e.g., enkephalin, tachykinin, insulin, and natriuretic peptides) by cleaving them; F18A12.8A is closely paralogous to ZK20.6, and orthologous to CG9761 in Drosophila melanogaster; F18A12.8 is homologous, and possibly orthologous, to human ECE1 (OMIM:600423; mutation leads to Hirschsprung disease, cardiac defects, and autonomic dysfunction); more generally, F18A12.8A falls into a group of proteins that includes the classical neprilysins found in mammals (e.g., PEX [OMIM:307800] and the enkephalin cleaving enzymes). |
GO Terms | metallopeptidase activity (GO:0008237) ; zinc ion binding (GO:0008270) ; proteolysis and peptidolysis (GO:0006508) ; neprilysin activity (GO:0004245) ; membrane (GO:0016020) |
Location | II:3420261..3425927 |
RNAi Phenotypes | No phenotypes observed. |
External Links | |
Associated RNAi Experiments | |
Cenix:243-c3 | |
Adult Phenotypes | WT |
RNAi Reagent Name & Type | Cenix:243-c3 (PCR reagent) |
Delivery Method | Injection |
Remark | Wildtype results in all three tests. |
Laboratory | TH |
Date | 2005-3-24 |
Reference | Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...." |
JA:F18A12.8 | |
Adult Phenotypes | WT |
RNAi Reagent Name & Type | sjj_F18A12.8 (PCR reagent) |
Laboratory | JA |
Date | 2003-1-10 |
Reference | Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...." |
Gene Plot of F18A12.8 | |