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Gene/ORF F18H3.5 (cdk-4) Ace View of F18H3.5
F18H3.5 Details Help
Description  cdk-4 encodes two isoforms of a cyclin-dependent serine/threonine protein kinase orthologous to human CDK4 and CDK6 (OMIM:123829 and OMIM:603368, mutated in cutanous malignant melanoma) which complex with D-type cyclins to regulate progression through the G1 phase of the cell cycle; CDK-4 activity is essential for G1 progression in postembryonic blast cells and as a result, cdk-4 mutant animals generally arrest during larval stages; the lethality generated by cdk mutations, also seen in animals doubly mutant for cdk-4 and cyd-1, a C. elegans D-type cyclin, can be suppressed by mutations in lin-35/Rb suggesting that, as in other organisms, LIN-35/Rb may be a major target of CDK-4/CYD-1 kinase activity; CDK-4 expression is first detected in neuronal and hypodermal lineages during mid-to-late embryogenesis, with postembryonic expression detected in hypodermal seam cells, cells of the P lineage which will give rise to ventral cord neurons, and cells of the somatic gonad, the vulva, and the intestine.
Homology Group (KOG)  Protein kinase PCTAIRE and related kinases
GO Terms  G1 phase of mitotic cell cycle (GO:0000080) ; post-embryonic development (GO:0009791) ; protein amino acid phosphorylation (GO:0006468) ; cell (GO:0005623) ; protein serine/threonine kinase activity (GO:0004674) ; protein kinase activity (GO:0004672) ; ATP binding (GO:0005524)
Location   X:13515374..13519224
RNAi Phenotypes
Larva Lvl
Adult Dpy ; Dpy ; Pvl ; Pvl ; Pvl ; Unc ; Unc ; Unc ; Rup ; Stp
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Summary
Cenix:147-h4
RNAi Reagent Name & Type Cenix:147-h4 (PCR reagent)
Delivery Method  Injection
Remark  post-embryonic: Adult Phenotype-Other
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
Cenix:57-g3
Adult Phenotypes  WT
RNAi Reagent Name & Type Cenix:57-g3 (PCR reagent)
Delivery Method  Injection
Remark  3/3 tests are wild type.
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
JA:F18H3.5
Adult Phenotypes  WT
RNAi Reagent Name & Type sjj_F18H3.5 (PCR reagent)
Laboratory  JA
Date  2003-1-10
Reference  Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...."
Simmer:F18H3.5:Repeat_a
Adult Phenotypes  Dpy
Pvl
Rup
Unc
RNAi Reagent Name & Type sjj_F18H3.5 (PCR reagent)
Laboratory  NL
Date  2003-10-01
Strain  NL4256 rrf-3(pk1426)
Reference  Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...."
Simmer:F18H3.5:Screen
Adult Phenotypes  Dpy
Pvl
Stp
Unc
RNAi Reagent Name & Type sjj_F18H3.5 (PCR reagent)
Laboratory  NL
Date  2003-10-01
Strain  NL4256 rrf-3(pk1426)
Reference  Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...."
Gene Plot of F18H3.5 Browse using GBrowse
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