Ace View of F18H3.5 | |||||
F18H3.5 Details | |||||
Description | cdk-4 encodes two isoforms of a cyclin-dependent serine/threonine protein kinase orthologous to human CDK4 and CDK6 (OMIM:123829 and OMIM:603368, mutated in cutanous malignant melanoma) which complex with D-type cyclins to regulate progression through the G1 phase of the cell cycle; CDK-4 activity is essential for G1 progression in postembryonic blast cells and as a result, cdk-4 mutant animals generally arrest during larval stages; the lethality generated by cdk mutations, also seen in animals doubly mutant for cdk-4 and cyd-1, a C. elegans D-type cyclin, can be suppressed by mutations in lin-35/Rb suggesting that, as in other organisms, LIN-35/Rb may be a major target of CDK-4/CYD-1 kinase activity; CDK-4 expression is first detected in neuronal and hypodermal lineages during mid-to-late embryogenesis, with postembryonic expression detected in hypodermal seam cells, cells of the P lineage which will give rise to ventral cord neurons, and cells of the somatic gonad, the vulva, and the intestine. | ||||
Homology Group (KOG) | Protein kinase PCTAIRE and related kinases |
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GO Terms | G1 phase of mitotic cell cycle (GO:0000080) ; post-embryonic development (GO:0009791) ; protein amino acid phosphorylation (GO:0006468) ; cell (GO:0005623) ; protein serine/threonine kinase activity (GO:0004674) ; protein kinase activity (GO:0004672) ; ATP binding (GO:0005524) | ||||
Location | X:13515374..13519224 | ||||
RNAi Phenotypes |
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External Links | |||||
Associated RNAi Experiments | |||||
Cenix:147-h4 | |||||
RNAi Reagent Name & Type | Cenix:147-h4 (PCR reagent) | ||||
Delivery Method | Injection | ||||
Remark | post-embryonic: Adult Phenotype-Other | ||||
Laboratory | TH | ||||
Date | 2005-3-24 | ||||
Reference | Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...." | ||||
Cenix:57-g3 | |||||
Adult Phenotypes | WT |
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RNAi Reagent Name & Type | Cenix:57-g3 (PCR reagent) | ||||
Delivery Method | Injection | ||||
Remark | 3/3 tests are wild type. | ||||
Laboratory | TH | ||||
Date | 2005-3-24 | ||||
Reference | Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...." | ||||
JA:F18H3.5 | |||||
Adult Phenotypes | WT |
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RNAi Reagent Name & Type | sjj_F18H3.5 (PCR reagent) | ||||
Laboratory | JA | ||||
Date | 2003-1-10 | ||||
Reference | Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...." | ||||
Simmer:F18H3.5:Repeat_a | |||||
Adult Phenotypes | Dpy Pvl Rup Unc |
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RNAi Reagent Name & Type | sjj_F18H3.5 (PCR reagent) | ||||
Laboratory | NL | ||||
Date | 2003-10-01 | ||||
Strain | NL4256 rrf-3(pk1426) | ||||
Reference | Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...." | ||||
Simmer:F18H3.5:Screen | |||||
Adult Phenotypes | Dpy Pvl Stp Unc |
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RNAi Reagent Name & Type | sjj_F18H3.5 (PCR reagent) | ||||
Laboratory | NL | ||||
Date | 2003-10-01 | ||||
Strain | NL4256 rrf-3(pk1426) | ||||
Reference | Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...." | ||||
Gene Plot of F18H3.5 | |||||