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Gene/ORF F26D10.3 (hsp-1) Ace View of F26D10.3
F26D10.3 Details Help
Description  hsp-1 encodes hsp70A, a member of the heat shock family of proteins; hsp70A is closely related to the Drosophila heat inducible hsp70s and the S. cerevisiae SSA hsp70 subfamily; the hsp-1 gene is normally expressed throughout development and upon heat-shock the hsp-1 mRNA is enhanced 2-6 fold; down-regulation of hsp-1 via RNA interference results in a small reduction in the life-span of an age-1 mutant indicating that hsp-1 may play some role in regulating longevity.
Homology Group (KOG)  Molecular chaperones HSP70/HSC70, HSP70 superfamily
GO Terms  response to heat (GO:0009408) ; determination of adult life span (GO:0008340) ; ATP binding (GO:0005524)
Location   IV:17278512..17281929
RNAi Phenotypes
Larva Lva ; Lva ; Lva ; Lva
Adult Dpy ; Sterile F0/Fertility Problems ; Unc ; Ste ; Ste ; Ste ; Sterility/Impaired Fertility in F0
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Summary
Cenix:122-e2
Adult Phenotypes  Sterile F0/Fertility Problems
Sterility/Impaired Fertility in F0
RNAi Reagent Name & Type Cenix:122-e2 (PCR reagent)
Delivery Method  Injection
Remark  early embryonic: Sterility/Impaired Fertility in F0
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
Simmer:F26D10.3
Adult Phenotypes  Ste
RNAi Reagent Name & Type sjj_F26D10.3 (PCR reagent)
Laboratory  NL
Date  2003-10-01
Strain  NL4256 rrf-3(pk1426)
Reference  Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...."
Simmer:T28F3.2
Larval Phenotypes  Lva
Adult Phenotypes  Ste brood size (1 out of 5)
RNAi Reagent Name & Type sjj_T28F3.2 (PCR reagent)
Laboratory  NL
Date  2003-10-01
Strain  NL4256 rrf-3(pk1426)
Reference  Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...."
Gene Plot of F26D10.3 Browse using GBrowse
Gene Map