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Gene/ORF F28B12.3 (vrk-1) Ace View of F28B12.3
F28B12.3 Details Help
Homology Group (KOG)  Casein kinase (serine/threonine/tyrosine protein kinase)
GO Terms  protein kinase activity (GO:0004672) ; ATP binding (GO:0005524) ; protein amino acid phosphorylation (GO:0006468) ; protein serine/threonine kinase activity (GO:0004674)
Location   II:5921531..5925202
RNAi Phenotypes
Early_embryo Indistinct maternal pronucleus ; P0 spindle absent ; Nuclear Appearance abnormal ; Aberrant nuclear reassembly ; Ectopic cleavage furrows ; Cytokinesis defect ; Excessive blebbing ; Large cytoplasmic granules ; Polar bodies abnormal ; Failure to form pronucleus
Larva Gro
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Summary
Cenix:12-h9
Embryonic Phenotypes  Emb Penetrance None reported
Adult Phenotypes  Nuclear Appearance abnormal
RNAi Reagent Name & Type Cenix:12-h9 (PCR reagent)
Delivery Method  Injection
Remark  early embryonic: Nuclear Appearance
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
JA:F28B12.3
Embryonic Phenotypes  Emb Penetrance 90 %
RNAi Reagent Name & Type sjj_F28B12.3 (PCR reagent)
Laboratory  JA
Date  2003-1-10
Reference  Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...."
PF:GL1_5G8
Embryonic Phenotypes  Emb Penetrance 100 %
Adult Phenotypes  Aberrant nuclear reassembly
Cytokinesis defect
Ectopic cleavage furrows
Excessive blebbing
Failure to form pronucleus
Indistinct maternal pronucleus
Large cytoplasmic granules
P0 spindle absent
Polar bodies abnormal
RNAi Reagent Name & Type sjj_F28B12.3 (PCR reagent)
Delivery Method  Injection
Remark  PCR product contains flanking T7 promoter sequences
Laboratory  KK
Date  2002-11-19
Reference  Piano et al. (2002) Curr Biol "Gene Clustering Based on RNAi Phenotypes of Ovary-Enriched Genes in C. elegans"
Movies/Stacks/Images  /static/images/movie.gif /static/images/movie.gif /static/images/movie.gif
Simmer:F28B12.3
Embryonic Phenotypes  Emb Penetrance 100 %
Larval Phenotypes  Gro
RNAi Reagent Name & Type sjj_F28B12.3 (PCR reagent)
Laboratory  NL
Date  2003-10-01
Strain  NL4256 rrf-3(pk1426)
Reference  Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...."
Gene Plot of F28B12.3 Browse using GBrowse
Gene Map