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Gene/ORF
F28B12.3 (vrk-1)
Ace View of F28B12.3
F28B12.3 Details
Homology Group (KOG)
Casein kinase (serine/threonine/tyrosine protein kinase)
GO Terms
protein kinase activity
(GO:0004672) ;
ATP binding
(GO:0005524) ;
protein amino acid phosphorylation
(GO:0006468) ;
protein serine/threonine kinase activity
(GO:0004674)
Location
II:5921531..5925202
RNAi Phenotypes
Early_embryo
Indistinct maternal pronucleus
;
P0 spindle absent
;
Nuclear Appearance abnormal
;
Aberrant nuclear reassembly
;
Ectopic cleavage furrows
;
Cytokinesis defect
;
Excessive blebbing
;
Large cytoplasmic granules
;
Polar bodies abnormal
;
Failure to form pronucleus
Larva
Gro
External Links
Associated RNAi Experiments
View Summary
Cenix:12-h9
Embryonic Phenotypes
Emb
Penetrance None reported
Adult Phenotypes
Nuclear Appearance abnormal
RNAi Reagent Name & Type
Cenix:12-h9 (PCR reagent)
Delivery Method
Injection
Remark
early embryonic: Nuclear Appearance
Laboratory
TH
Date
2005-3-24
Reference
Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
JA:F28B12.3
Embryonic Phenotypes
Emb
Penetrance 90 %
RNAi Reagent Name & Type
sjj_F28B12.3 (PCR reagent)
Laboratory
JA
Date
2003-1-10
Reference
Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...."
PF:GL1_5G8
Embryonic Phenotypes
Emb
Penetrance 100 %
Adult Phenotypes
Aberrant nuclear reassembly
Cytokinesis defect
Ectopic cleavage furrows
Excessive blebbing
Failure to form pronucleus
Indistinct maternal pronucleus
Large cytoplasmic granules
P0 spindle absent
Polar bodies abnormal
RNAi Reagent Name & Type
sjj_F28B12.3 (PCR reagent)
Delivery Method
Injection
Remark
PCR product contains flanking T7 promoter sequences
Laboratory
KK
Date
2002-11-19
Reference
Piano et al. (2002) Curr Biol "Gene Clustering Based on RNAi Phenotypes of Ovary-Enriched Genes in C. elegans"
Movies/Stacks/Images
Simmer:F28B12.3
Embryonic Phenotypes
Emb
Penetrance 100 %
Larval Phenotypes
Gro
RNAi Reagent Name & Type
sjj_F28B12.3 (PCR reagent)
Laboratory
NL
Date
2003-10-01
Strain
NL4256 rrf-3(pk1426)
Reference
Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...."
Gene Plot of F28B12.3
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