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Gene/ORF F35B12.5 (sas-5) Ace View of F35B12.5
F35B12.5 Details Help
Description  sas-5 encodes a coiled-coil protein whose activity is required, paternally, maternally, and in a dose-dependent manner, for daughter centriole formation; SAS-5 localizes to both the cytoplasm and to centrioles, and photobleaching experiments reveal rapid SAS-5 cycling between these two cellular components throughout the cell cycle; SAS-5 localization to centrioles depends upon the ZYG-1 kinase and the SAS-6 coiled-coil protein, two proteins also required for centriole duplication; in turn, SAS-5 activity is required for SAS-6 centriolar localization, as SAS-6 fails to localize properly in sas-5 mutant embryos.
Location   V:11612935..11616044
RNAi Phenotypes
Early_embryo Abnormal blebbing ; Spindle Assembly abnormal ; Cytokinesis problems ; Multiple nuclei
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Details
Experiments with Non-Wild Phenotypes
JA:F35B12.5 Emb
Cenix:34-g2 Emb ; Spindle Assembly abnormal
Simmer:F35B12.5 Emb
Gene Plot of F35B12.5 Browse using GBrowse
Gene Map