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Gene/ORF F43E2.8 (hsp-4) Ace View of F43E2.8
F43E2.8 Details Help
Description  hsp-4 encodes a predicted homolog of the mammalian ER chaperone BiP that affects embryonic and larval viability; expression is most prominent in the spermatheca and transcription of hsp-4 is induced in the gut and in the hypodermis upon ER stress.
Homology Group (KOG)  Molecular chaperones GRP78/BiP/KAR2, HSP70 superfamily
GO Terms  response to stress (GO:0006950) ; protein folding (GO:0006457) ; embryonic development (GO:0009790) ; endoplasmic reticulum (GO:0005783) ; ATP binding (GO:0005524)
Location   II:7349650..7352967
RNAi Phenotypes
Early_embryo Osmotic Integrity defective
Larva Lva ; Lva ; Gro
Adult Sterile F0/Fertility Problems ; Ste
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Details
Adult Phenotypes  Sterile F0/Fertility Problems
Adult Phenotypes  Osmotic Integrity defective
RNAi Reagent Name & Type Cenix:147-h12 (PCR reagent)
Delivery Method  Injection
Remark  early embryonic: Osmotic Integrity
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
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