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Gene/ORF F43G6.1 (dna-2) Ace View of F43G6.1
F43G6.1 Details Help
Description  dna-2 encodes the C. elegans ortholog of the yeast and vertebrate Dna2 replication helicases; by homology, DNA-2 is predicted to function as an endonuclease and an ATP-dependent helicase that is involved in DNA replication and repair; in C. elegans, DNA-2 activity is required maternally and zygotically to maintain normal rates of cell division and for proper germ-line, embryonic, and larval development; DNA-2 activity is temperature-sensitive: animals lacking DNA-2 at 16 degrees Celsius (C) are less severely affected than those at 20 or 25 degrees C; in the hermaphrodite gonad, DNA-2 localizes to nuclei of germ cells and developing oocytes, and expression continues in embryos up to the comma stage; DNA-2 then reappears at the L3 larval stage, and in L3 and L4 larvae is visible in the proliferating somatic cells of the uterus and spermatheca.
Homology Group (KOG)  DNA replication helicase
Location   II:11777658..11782524
RNAi Phenotypes No phenotypes observed.
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Details
Wild Type RNAi Experiments
JA:F43G6.1 WT
Cenix:200-a6 WT
Experiments with Non-Wild Phenotypes
PF:GL1_3A5 Emb
Gene Plot of F43G6.1 Browse using GBrowse
Gene Map