Ace View of F45E10.1 | |
F45E10.1 Details | |
Description | UNC-53 encodes at least five large (~1200-1600 residue) proteins, orthologous to human NAV1, NAV2/RAINB1 (OMIM:607026), and NAV3, and homologous to Drosophila CG10662; UNC-53 proteins are required for anteroposterior guidance of migrating cells and axons, and for egg-laying, correct backward locomotion, full body size, and male mating; UNC-53 proteins vary in their N-terminal regions but share common C-terminal sequences with an AAA-ATPase domain; UNC-71 binds B0336.6 in a yeast two-hybrid screen, and interacts both physically and genetically with SEM-5; unc-53 is expressed in those cells requiring it, suggesting that its function is cell-autonomous; overexpression of unc-53 induces excess cellular outgrowth. |
GO Terms | positive regulation of axon extension (GO:0045773) ; mesoderm cell migration (GO:0008078) ; positive regulation of cell migration (GO:0030335) ; oviposition (GO:0018991) ; axon guidance (GO:0007411) ; signal transduction (GO:0007165) ; backward locomotion (GO:0043057) ; positive regulation of body size (GO:0040018) ; cytoplasm (GO:0005737) ; actin filament binding (GO:0051015) ; protein domain specific binding (GO:0019904) ; nucleotide binding (GO:0000166) ; mating behavior (GO:0007617) ; determination of muscle attachment site (GO:0016204) ; actin cytoskeleton organization and biogenesis (GO:0030036) |
Location | II:11057616..11089771 |
RNAi Phenotypes | No phenotypes observed. |
External Links | |
Associated RNAi Experiments | |
Cenix:148-h1 | |
Adult Phenotypes | WT |
RNAi Reagent Name & Type | Cenix:148-h1 (PCR reagent) |
Delivery Method | Injection |
Laboratory | TH |
Date | 2005-3-24 |
Reference | Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...." |
JA:F45E10.1 | |
Adult Phenotypes | WT |
RNAi Reagent Name & Type | sjj_F45E10.1 (PCR reagent) |
Laboratory | JA |
Date | 2003-1-10 |
Reference | Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...." |
Gene Plot of F45E10.1 | |