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Gene/ORF F45E10.1 (unc-53) Ace View of F45E10.1
F45E10.1 Details Help
Description  UNC-53 encodes at least five large (~1200-1600 residue) proteins, orthologous to human NAV1, NAV2/RAINB1 (OMIM:607026), and NAV3, and homologous to Drosophila CG10662; UNC-53 proteins are required for anteroposterior guidance of migrating cells and axons, and for egg-laying, correct backward locomotion, full body size, and male mating; UNC-53 proteins vary in their N-terminal regions but share common C-terminal sequences with an AAA-ATPase domain; UNC-71 binds B0336.6 in a yeast two-hybrid screen, and interacts both physically and genetically with SEM-5; unc-53 is expressed in those cells requiring it, suggesting that its function is cell-autonomous; overexpression of unc-53 induces excess cellular outgrowth.
GO Terms  positive regulation of axon extension (GO:0045773) ; mesoderm cell migration (GO:0008078) ; positive regulation of cell migration (GO:0030335) ; oviposition (GO:0018991) ; axon guidance (GO:0007411) ; signal transduction (GO:0007165) ; backward locomotion (GO:0043057) ; positive regulation of body size (GO:0040018) ; cytoplasm (GO:0005737) ; actin filament binding (GO:0051015) ; protein domain specific binding (GO:0019904) ; nucleotide binding (GO:0000166) ; mating behavior (GO:0007617) ; determination of muscle attachment site (GO:0016204) ; actin cytoskeleton organization and biogenesis (GO:0030036)
Location   II:11057616..11089771
RNAi Phenotypes No phenotypes observed.
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Details
Cenix:148-h1
Adult Phenotypes  WT
RNAi Reagent Name & Type Cenix:148-h1 (PCR reagent)
Delivery Method  Injection
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
JA:F45E10.1
Adult Phenotypes  WT
RNAi Reagent Name & Type sjj_F45E10.1 (PCR reagent)
Laboratory  JA
Date  2003-1-10
Reference  Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...."
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