Ace View of F45H11.4 | |
F45H11.4 Details | |
Description | mgl-2 encodes a Group I metabotropic glutamate receptor (OMIM:604473, 604102, loss-of-function mutations in mice are associated with defects in long-term potentiation); by homology, MGL-2 is predicted to function as a post-synaptic G protein-coupled receptor that, in response to glutamate binding, stimulates phospholipase C activity and increases neuronal excitation, and in mammalian tissue culture cells, glutamate stimulation of MGL-2 does result in increased phosphoinositide turnover; a mutation in mgl-2 indicates that it is required for normal head movements and tap reversal reflexes, while loss of mgl-2 activity via large-scale RNAi screens indicates that MGL-2 is also required for embryogenesis; a mgl-2::GFP reporter is expressed in interneurons. |
Homology Group (KOG) | Glutamate-gated metabotropic ion channel receptor subunit GRM2 and related subunits, G-protein coupled receptor superfamily bZIP transcription factor MafK |
GO Terms | metabotropic glutamate, GABA-B-like receptor activity (GO:0008067) ; membrane (GO:0016020) ; G-protein coupled receptor activity (GO:0004930) ; DNA binding (GO:0003677) ; regulation of transcription, DNA-dependent (GO:0006355) ; nucleus (GO:0005634) |
Location | I:10382355..10391704 |
RNAi Phenotypes | No phenotypes observed. |
External Links | |
Associated RNAi Experiments | |
Cenix:57-a5 | |
Adult Phenotypes | WT |
RNAi Reagent Name & Type | Cenix:57-a5 (PCR reagent) |
Delivery Method | Injection |
Remark | early embryonic: Only low reproducible defects found. |
Laboratory | TH |
Date | 2005-3-24 |
Reference | Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...." |
JA:F45H11.4 | |
Adult Phenotypes | WT |
RNAi Reagent Name & Type | sjj_F45H11.4 (PCR reagent) |
Laboratory | JA |
Date | 2000-11-16 |
Reference | Fraser AG et al. (2000) Nature "Functional genomic analysis of C. elegans chromosome I by systematic RNA ...." |
Gene Plot of F45H11.4 | |