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Gene/ORF F45H11.4 (mgl-2) Ace View of F45H11.4
F45H11.4 Details Help
Description  mgl-2 encodes a Group I metabotropic glutamate receptor (OMIM:604473, 604102, loss-of-function mutations in mice are associated with defects in long-term potentiation); by homology, MGL-2 is predicted to function as a post-synaptic G protein-coupled receptor that, in response to glutamate binding, stimulates phospholipase C activity and increases neuronal excitation, and in mammalian tissue culture cells, glutamate stimulation of MGL-2 does result in increased phosphoinositide turnover; a mutation in mgl-2 indicates that it is required for normal head movements and tap reversal reflexes, while loss of mgl-2 activity via large-scale RNAi screens indicates that MGL-2 is also required for embryogenesis; a mgl-2::GFP reporter is expressed in interneurons.
Homology Group (KOG)  Glutamate-gated metabotropic ion channel receptor subunit GRM2 and related subunits, G-protein coupled receptor superfamily
bZIP transcription factor MafK
GO Terms  metabotropic glutamate, GABA-B-like receptor activity (GO:0008067) ; membrane (GO:0016020) ; G-protein coupled receptor activity (GO:0004930) ; DNA binding (GO:0003677) ; regulation of transcription, DNA-dependent (GO:0006355) ; nucleus (GO:0005634)
Location   I:10382355..10391704
RNAi Phenotypes No phenotypes observed.
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Details
Cenix:57-a5
Adult Phenotypes  WT
RNAi Reagent Name & Type Cenix:57-a5 (PCR reagent)
Delivery Method  Injection
Remark  early embryonic: Only low reproducible defects found.
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
JA:F45H11.4
Adult Phenotypes  WT
RNAi Reagent Name & Type sjj_F45H11.4 (PCR reagent)
Laboratory  JA
Date  2000-11-16
Reference  Fraser AG et al. (2000) Nature "Functional genomic analysis of C. elegans chromosome I by systematic RNA ...."
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