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Gene/ORF F46A9.4 (skr-2) Ace View of F46A9.4
F46A9.4 Details Help
Description  skr-2 encodes a homolog of Skp1 in S. cerevisiae, a core component of the SCF (Skp1p, Cullin, F-box) ubiquitin-ligase complex that facilitates ubiquitin-mediated protein degradation; SKR-2 is required for the restraint of cell proliferation, progression through the pachytene stage of meiosis, and the formation of bivalent chromosomes at diakinesis; SKR-2::GFP is detected exclusively in the intestine.
Homology Group (KOG)  SCF ubiquitin ligase, Skp1 component
GO Terms  negative regulation of cell proliferation (GO:0008285) ; pachytene (GO:0000239) ; mitotic spindle orientation (GO:0000132) ; embryonic development (sensu Animalia) (GO:0009792) ; SCF ubiquitin ligase complex (GO:0019005) ; molecular_function unknown (GO:0005554)
Location   I:9469280..9471023
RNAi Phenotypes
Early_embryo Spn
Postembryonic WT_postembryonic_morphology
Larva Lva ; Gro
Adult Gon ; Egl ; Pvl ; Unc ; Unc
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Details
Experiments with Non-Wild Phenotypes
Cenix:16-h1 Emb ; WT_postembryonic_morphology
Simmer:F46A9.4:Screen_B Emb
PF:GL1_3A2 Egl ; Emb ; Gon
JA:F46A9.4 Emb ; Gro ; Pvl ; Spn ; Unc
Simmer:F46A9.4:Screen_A Emb ; Lva ; Unc
Gene Plot of F46A9.4 Browse using GBrowse
Gene Map