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Gene/ORF F46F3.1 (ceh-27) Ace View of F46F3.1
F46F3.1 Details Help
Description  ceh-27 encodes a homeodomain protein of the NK-2 class that contains Drosophila scarecrow and human NKX-2 (OMIM:606727); CEH-27 activity is essential for embryogenesis and appears to be required for maintaining hypodermal integrity during movement as embryos lacking CEH-27 burst at a breach in the ventral hypodermis upon commencement of muscle contractions; CEH-27 expression is first detected in the ~100-cell embryo in what appear to be MS-derived cells while in later embryos expression is seen in a number of cells in the anterior head region.
Homology Group (KOG)  Transcription factor tinman/NKX2-3, contains HOX domain
GO Terms  DNA binding (GO:0003677) ; transcription factor activity (GO:0003700) ; regulation of transcription, DNA-dependent (GO:0006355) ; nucleus (GO:0005634) ; regulation of transcription (GO:0045449)
Location   V:11663860..11667687
RNAi Phenotypes
Postembryonic WT_postembryonic_morphology
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Details
Embryonic Phenotypes  Emb Penetrance None reported
Adult Phenotypes  WT_postembryonic_morphology
RNAi Reagent Name & Type Cenix:41-e2 (PCR reagent)
Delivery Method  Injection
Remark  early embryonic: No significant defects seen.
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
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