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Gene/ORF F47F6.1 (lin-42) Ace View of F47F6.1
F47F6.1 Details Help
Description  lin-42 encodes a PAS domain-containing protein orthologous to the insect and mammalian Period proteins that function in the timing of circadian rhythms; during postembryonic development, lin-42 activity is required for the switch from larval to adult fates that occurs in the hypodermal seam cells during the fourth and final molt; as a component of the heterochronic pathway, genetic analysis suggests that lin-42 likely acts early in the heterochronic pathway, either downstream of or in parallel to lin-46, which encodes a predicted scaffolding protein required for L3- and adult-specific cell fates; during larval development, lin-42 mRNA levels oscillate with peak levels apparent during larval intermolts and low levels seen during ecdysis and after the L4-to-adult molt; a rescuing LIN-42::GFP fusion protein is expressed in lateral hypodermal cells, the hypodermal syncytium, and head and tail hypodermal cells beginning during late embryogenesis and continuing through adulthood; within cells, LIN-42 is detected at generally higher levels in nuclei than in cytoplasm, although expression in the latter is enhanced during the larval molts.
GO Terms  regulation of transcription, DNA-dependent (GO:0006355) ; signal transduction (GO:0007165) ; signal transducer activity (GO:0004871)
Location   II:1233556..1244441
RNAi Phenotypes
Adult Dpy ; Dpy ; Dpy ; Dpy ; Egl ; Egl ; Egl ; Pvl ; Pvl ; Unc ; Rup ; Rup ; Rup
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Summary
Cenix:162-a6
Adult Phenotypes  WT
RNAi Reagent Name & Type Cenix:162-a6 (PCR reagent)
Delivery Method  Injection
Remark  Wildtype results in all three tests.
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
Cenix:162-h5
Adult Phenotypes  WT
RNAi Reagent Name & Type Cenix:162-h5 (PCR reagent)
Delivery Method  Injection
Remark  3/3 tests are wildtype
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
Cenix:246-b9
Adult Phenotypes  Dpy
RNAi Reagent Name & Type Cenix:246-b9 (PCR reagent)
Delivery Method  Injection
Remark  post-embryonic: Adult Phenotype-Dumpy (dpy)
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
JA:F47F6.1
Adult Phenotypes  WT
RNAi Reagent Name & Type sjj_F47F6.1 (PCR reagent)
Laboratory  JA
Date  2003-1-10
Reference  Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...."
JA:F47F6.2
Adult Phenotypes  WT
RNAi Reagent Name & Type sjj_F47F6.2 (PCR reagent)
Laboratory  JA
Date  2003-1-10
Reference  Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...."
Simmer:F47F6.1:Repeat_a
Adult Phenotypes  Dpy
Egl
Pvl
RNAi Reagent Name & Type sjj_F47F6.1 (PCR reagent)
Laboratory  NL
Date  2003-10-01
Strain  NL4256 rrf-3(pk1426)
Reference  Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...."
Simmer:F47F6.1:Screen
Adult Phenotypes  Dpy
Egl
Pvl
Rup
RNAi Reagent Name & Type sjj_F47F6.1 (PCR reagent)
Laboratory  NL
Date  2003-10-01
Strain  NL4256 rrf-3(pk1426)
Reference  Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...."
Simmer:F47F6.2:Repeat_a
Adult Phenotypes  Rup
Unc
RNAi Reagent Name & Type sjj_F47F6.2 (PCR reagent)
Laboratory  NL
Date  2003-10-01
Strain  NL4256 rrf-3(pk1426)
Reference  Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...."
Simmer:F47F6.2:Screen
Adult Phenotypes  Dpy
Egl
Rup
RNAi Reagent Name & Type sjj_F47F6.2 (PCR reagent)
Laboratory  NL
Date  2003-10-01
Strain  NL4256 rrf-3(pk1426)
Reference  Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...."
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