Ace View of F47F6.1 | |||
F47F6.1 Details | |||
Description | lin-42 encodes a PAS domain-containing protein orthologous to the insect and mammalian Period proteins that function in the timing of circadian rhythms; during postembryonic development, lin-42 activity is required for the switch from larval to adult fates that occurs in the hypodermal seam cells during the fourth and final molt; as a component of the heterochronic pathway, genetic analysis suggests that lin-42 likely acts early in the heterochronic pathway, either downstream of or in parallel to lin-46, which encodes a predicted scaffolding protein required for L3- and adult-specific cell fates; during larval development, lin-42 mRNA levels oscillate with peak levels apparent during larval intermolts and low levels seen during ecdysis and after the L4-to-adult molt; a rescuing LIN-42::GFP fusion protein is expressed in lateral hypodermal cells, the hypodermal syncytium, and head and tail hypodermal cells beginning during late embryogenesis and continuing through adulthood; within cells, LIN-42 is detected at generally higher levels in nuclei than in cytoplasm, although expression in the latter is enhanced during the larval molts. | ||
GO Terms | regulation of transcription, DNA-dependent (GO:0006355) ; signal transduction (GO:0007165) ; signal transducer activity (GO:0004871) | ||
Location | II:1233556..1244441 | ||
RNAi Phenotypes |
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External Links | |||
Associated RNAi Experiments | |||
Cenix:162-a6 | |||
Adult Phenotypes | WT |
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RNAi Reagent Name & Type | Cenix:162-a6 (PCR reagent) | ||
Delivery Method | Injection | ||
Remark | Wildtype results in all three tests. | ||
Laboratory | TH | ||
Date | 2005-3-24 | ||
Reference | Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...." | ||
Cenix:162-h5 | |||
Adult Phenotypes | WT |
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RNAi Reagent Name & Type | Cenix:162-h5 (PCR reagent) | ||
Delivery Method | Injection | ||
Remark | 3/3 tests are wildtype | ||
Laboratory | TH | ||
Date | 2005-3-24 | ||
Reference | Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...." | ||
Cenix:246-b9 | |||
Adult Phenotypes | Dpy |
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RNAi Reagent Name & Type | Cenix:246-b9 (PCR reagent) | ||
Delivery Method | Injection | ||
Remark | post-embryonic: Adult Phenotype-Dumpy (dpy) | ||
Laboratory | TH | ||
Date | 2005-3-24 | ||
Reference | Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...." | ||
JA:F47F6.1 | |||
Adult Phenotypes | WT |
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RNAi Reagent Name & Type | sjj_F47F6.1 (PCR reagent) | ||
Laboratory | JA | ||
Date | 2003-1-10 | ||
Reference | Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...." | ||
JA:F47F6.2 | |||
Adult Phenotypes | WT |
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RNAi Reagent Name & Type | sjj_F47F6.2 (PCR reagent) | ||
Laboratory | JA | ||
Date | 2003-1-10 | ||
Reference | Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...." | ||
Simmer:F47F6.1:Repeat_a | |||
Adult Phenotypes | Dpy Egl Pvl |
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RNAi Reagent Name & Type | sjj_F47F6.1 (PCR reagent) | ||
Laboratory | NL | ||
Date | 2003-10-01 | ||
Strain | NL4256 rrf-3(pk1426) | ||
Reference | Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...." | ||
Simmer:F47F6.1:Screen | |||
Adult Phenotypes | Dpy Egl Pvl Rup |
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RNAi Reagent Name & Type | sjj_F47F6.1 (PCR reagent) | ||
Laboratory | NL | ||
Date | 2003-10-01 | ||
Strain | NL4256 rrf-3(pk1426) | ||
Reference | Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...." | ||
Simmer:F47F6.2:Repeat_a | |||
Adult Phenotypes | Rup Unc |
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RNAi Reagent Name & Type | sjj_F47F6.2 (PCR reagent) | ||
Laboratory | NL | ||
Date | 2003-10-01 | ||
Strain | NL4256 rrf-3(pk1426) | ||
Reference | Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...." | ||
Simmer:F47F6.2:Screen | |||
Adult Phenotypes | Dpy Egl Rup |
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RNAi Reagent Name & Type | sjj_F47F6.2 (PCR reagent) | ||
Laboratory | NL | ||
Date | 2003-10-01 | ||
Strain | NL4256 rrf-3(pk1426) | ||
Reference | Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...." | ||
Gene Plot of F47F6.1 | |||