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Gene/ORF F53G12.5 (mex-3) Ace View of F53G12.5
F53G12.5 Details Help
Description  mex-3 encodes two KH domain-containing RNA binding proteins; in the early embryo, maternally provided MEX-3 is required for specifying the identities of the anterior AB blastomere and its descendants, as well as for the identity of the P3 blastomere and proper segregation of the germline P granules; mex-3 mRNA is distributed uniformly in the syncytial core of the adult distal gonad, mature oocytes, and early 1-cell stage embryos, but then becomes more prominent in the AB blastomere and its daughters by the 4-cell stage after which it is rapidly degraded save for the D and P4 blastomeres; MEX-3 protein is also detected uniformly in the cytoplasm of oocytes and 1-cell stage embryos, but like the mRNA, becomes more abundant in AB and its daughters at the 2- and 4-cell stages, respectively, before disappearing; MEX-3 is also detected in association with P granules from the 2-cell stage until the late stages of embryogenesis.
Homology Group (KOG)  Predicted RNA binding protein, contains KH domain
GO Terms  embryonic pattern specification (GO:0009880) ; cell fate specification (GO:0001708) ; organelle inheritance (GO:0048308) ; negative regulation of muscle cell differentiation (GO:0051148) ; negative regulation of translation (GO:0016478) ; cytoplasm (GO:0005737) ; P granule (GO:0043186) ; single-stranded RNA binding (GO:0003727) ; nucleic acid binding (GO:0003676)
Location   I:126897..134642
RNAi Phenotypes
Early_embryo Cytokinesis problems
Postembryonic WT_postembryonic_morphology
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Details
Experiments with Non-Wild Phenotypes
Simmer:F53G12.5:Screen_B Emb
JA:F53G12.5 Emb ; Led
Cenix:75-f1 Emb ; WT_postembryonic_morphology
Simmer:F53G12.5:Screen_A Emb
Gene Plot of F53G12.5 Browse using GBrowse
Gene Map