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Gene/ORF F57C12.4 (mrp-2) Ace View of F57C12.4
F57C12.4 Details Help
Description  mrp-2 encodes a predicted multidomain transmembrane protein that is a member of the ATP-binding cassette (ABC) superfamily of transport proteins and is homologous to the human multidrug resistance-associated protein 1 (MRP1, OMIM:158343); by homology, MRP-2 is predicted to function as a membrane pump that couples the energy of ATP hydrolysis to membrane transport; as loss of MRP-2 function via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of MRP-2 in C. elegans development and/or behavior is not yet known; mrp-2 expression is, however, upregulated early in the exit from the alternative dauer stage and then remains induced, suggesting that MRP-2 activity is required for the transition to, and maintenance of, a more active metabolic state.
Homology Group (KOG)  Multidrug resistance-associated protein/mitoxantrone resistance protein, ABC superfamily
GO Terms  nucleotide binding (GO:0000166) ; nucleoside triphosphatase activity (GO:0017111) ; ATP binding (GO:0005524) ; ATPase activity, coupled to transmembrane movement of substances (GO:0042626) ; transport (GO:0006810) ; integral to membrane (GO:0016021) ; ATPase activity (GO:0016887) ; transporter activity (GO:0005215) ; DNA binding (GO:0003677) ; nucleus (GO:0005634)
Location   X:563335..573044
RNAi Phenotypes No phenotypes observed.
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Details
Cenix:53-a12
Adult Phenotypes  WT
RNAi Reagent Name & Type Cenix:53-a12 (PCR reagent)
Delivery Method  Injection
Remark  3/3 tests are wildtype.
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
JA:F57C12.4
Adult Phenotypes  WT
RNAi Reagent Name & Type sjj_F57C12.4 (PCR reagent)
Laboratory  JA
Date  2003-1-10
Reference  Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...."
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