Gene/ORF
F57C12.4 (mrp-2)
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Ace View of F57C12.4
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F57C12.4 Details |
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Description |
mrp-2 encodes a predicted multidomain transmembrane protein that is a member of the ATP-binding cassette (ABC) superfamily of transport proteins and is homologous to the human multidrug resistance-associated protein 1 (MRP1, OMIM:158343); by homology, MRP-2 is predicted to function as a membrane pump that couples the energy of ATP hydrolysis to membrane transport; as loss of MRP-2 function via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of MRP-2 in C. elegans development and/or behavior is not yet known; mrp-2 expression is, however, upregulated early in the exit from the alternative dauer stage and then remains induced, suggesting that MRP-2 activity is required for the transition to, and maintenance of, a more active metabolic state. |
Homology Group (KOG) |
Multidrug resistance-associated protein/mitoxantrone resistance protein, ABC superfamily
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GO Terms |
nucleotide binding
(GO:0000166) ; nucleoside triphosphatase activity
(GO:0017111) ; ATP binding
(GO:0005524) ; ATPase activity, coupled to transmembrane movement of substances
(GO:0042626) ; transport
(GO:0006810) ; integral to membrane
(GO:0016021) ; ATPase activity
(GO:0016887) ; transporter activity
(GO:0005215) ; DNA binding
(GO:0003677) ; nucleus
(GO:0005634) |
Location |
X:563335..573044 |
RNAi Phenotypes |
No phenotypes observed.
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External Links |
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Associated RNAi Experiments |
View Details
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Cenix:53-a12
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Adult Phenotypes |
WT
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RNAi Reagent Name & Type |
Cenix:53-a12 (PCR reagent) |
Delivery Method |
Injection |
Remark |
3/3 tests are wildtype. |
Laboratory |
TH |
Date |
2005-3-24 |
Reference |
Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...." |
JA:F57C12.4
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Adult Phenotypes |
WT
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RNAi Reagent Name & Type |
sjj_F57C12.4 (PCR reagent) |
Laboratory |
JA |
Date |
2003-1-10 |
Reference |
Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...." |
Gene Plot of F57C12.4 |
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